15 documents found, page 1 of 2

Glioblastoma as an Advanced Parkinson’s Disease Mimicker

Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistan...

Background and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therap...

Fortaleza da gastronomia de rua

Governo do Estado do Ceará Secretaria da Cultura do Estado do Ceará (SECULT) Instituto Dragão do Mar (IDM) Fundo Estadual de Combate à Pobreza (FECOP) Centro Cultural Grande Bom Jardim (CCBJ)

Glioblastoma: is there any blood biomarker with true clinical relevance?

Glioblastoma (GBM) is the most frequent malignant primary brain tumor in adults, characterized by a highly aggressive, inflammatory and angiogenic phenotype. It is a remarkably heterogeneous tumor at several levels, including histopathologically, radiographically and genetically. The 2016 update of the WHO Classification of Tumours of the Central Nervous System highlighted molecular parameters as paramount feat...

Serum lactate levels are associated with glioma malignancy grade

Objective Recent studies have suggested that high grade gliomas are associated with elevated serum lactate concentrations. The aim of the present study is to assess these findings in a sample of patients. Patients and methods We reviewed the anesthetic charts of patients with low-grade and high-grade glioma who underwent resection surgery and collected serum lactate concentration before tumor resection, as well...

Genetic variants of vascular endothelial growth factor predict risk and surviva...

The vascular endothelial growth factor regulates angiogenesis that is increased in glioma. VEGF polymorphisms are thought to modulate vascular endothelial growth factor plasma levels and therefore may be implicated in glioma risk. We aimed to clarify the role of VEGF and von Willebrand factor polymorphisms in glioma susceptibility and prognosis. A case-control study of 126 glioma patients and 180 cancer-free co...

Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in gl...

Abnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor ...

Padrão de Consumo de Olerícolas durante o Período Gestacional

Durante a gestação ocorrem algumas alterações no metabolismo materno, com isso, ocorre o aumento das necessidades nutricionais para garantir o adequado crescimento e desenvolvimento fetal. Para isso, são necessárias adaptações nutricionais para suprir essa necessidade aumentada, ocorrendo a introdução de suplementos de alguns nutrientes, como ferro e ácido fólico. O objetivo do presente artigo é definir o perfi...

Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient pr...

Transforming growth factor beta (TGF-ß) plays an important role in carcinogenesis. Two polymorphisms in the TGF-ß1 gene (-509C/T and 869T/C) were described to influence susceptibility to gastric and breast cancers. The 869T/C polymorphism was also associated with overall survival in breast cancer patients. In the present study, we investigated the relevance of these TGF-ß1 polymorphism in glioma risk and progno...

Immunoglobulin genes implicated in glioma risk

Both genetic and environmental factors are thought to be causal in gliomagenesis. Several genes have been implicated in glioma development, but the putative role of a major immunity-related gene complex member, immunoglobulin heavy chain ? (IGHG) has not been evaluated. Prior observations that IGHG-encoded ? marker (GM) allotypes exhibit differential sensitivity to an immunoevasion strategy of cytomegalovirus, ...