Encontrados 2 documentos, a visualizar página 1 de 1
Biodegradable polymeric nanocapsules prevent cardiotoxicity of anti-trypanosoma...
Branquinho, Renata Tupinambá; Roy, Jérôme; Farah, Charlotte; Garcia, Giani Martins; Aimond, Franck; Guennec, Jean Yves LeChagas disease is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi. New antitrypanosomal options are desirable to prevent complications, including a high rate of cardiomyopathy. Recently, a natural substance, lychnopholide, has shown therapeutic potential, especially when encapsulated in biodegradable polymeric nanocapsules. However, little is known regarding possible adverse effects of l...
Polymeric nanocapsules prevent oxidation of core-loaded molecules : evidence ba...
Roy, Jérôme; Oliveira, Liliam Teixeira; Oger, Camille; Galano, Jean Marie; Poncé, Valerie Bultel; Richard, Sylvain; Guimarães, Andrea GrabeBackground: Nanocapsules, as a delivery system, are able to target drugs and other biologically sensitive molecules to specific cells or organs. This system has been intensively investigated as a way to protect bioactives drugs from inactivation upon interaction with the body and to ensure the release to the target. However, the mechanism of improved activity of the nanoencapsulated molecules is far from being ...