2 documents found, page 1 of 1
Mulberry biomass-derived nanomedicines mitigate colitis through improved inflam...
Yang, Wenjing; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Wu, Jiaxue; Xu, Cheng; Sun, Wei; Zhao, Erhu; Wang, Min; Reis, R. L.; Kundu, Subhas C; Shi, XiaoxiaoThe therapeutic outcomes of conventional oral medications against ulcerative colitis (UC) are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment. Herein, a fluorinated pluronic (FP127) was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles (MLNs) loading with resveratrol nanocrystals (RNs). The o...
Dual-driven nanomotors enable tumour penetration and hypoxia alleviation for ca...
Wu, Jiaxue; Yi, Shixiong; Cao, Yingui; Zu, Menghang; Li, Baoyi; Yang, Wenjing; Shahbazi, Mohammad-Ali; Wan, Ying; Reis, R. L.; Kundu, Subhas CThe treatment efficacies of conventional medications against colorectal cancer (CRC) are restricted by a low penetrative, hypoxic, and immunosuppressive tumor microenvironment. To address these restrictions, we developed an innovative antitumor platform that employs calcium overload-phototherapy using mitochondrial N770-conjugated mesoporous silica nanoparticles loaded with CaO2 (CaO2–N770@MSNs). A loading leve...