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Global variation in lipoprotein/a levels among patients with coronary heart dis...

Barkas, Fotios; Brandts, Julia; De Bacquer, Dirk; Jennings, Catriona; De Backer, Guy G.; Kotseva, Kornelia; Ryden, Lars; Lip, Gregory Y. H.

Background Lipoprotein(a) [Lp(a)] is a common risk factor for atherosclerotic cardiovascular disease, potentially more atherogenic per particle than low-density lipoprotein. An estimated 1.5 billion individuals globally have elevated levels ≥125 nmol/L, considered as a risk-enhancing threshold. Although Lp(a) levels vary by ethnicity, ongoing trials of novel therapies in predominantly secondary prevention patie...


Frequency of residual combined dyslipidemia and hypertriglyceridemia in patient...

Santos, Raul D.; Ray, Kausik K.; De Bacquer, Dirk; Jennings, Catriona; Kotseva, Kornelia; Rydén, Lars; Lip, Gregory Y. H.; Erlund, Iris; Ganly, Sandra

Background and aims: Hypertriglyceridemia (HTG) is independently associated with risk of atherosclerotic events, even when LDL-cholesterol levels appear controlled. This INTERASPIRE study determined the frequency of HTG and residual combined dyslipidemia and their related factors in patients with coronary heart disease (CHD) from 13 countries across six World Health Organization (WHO) regions. Methods: Particip...


An international multidisciplinary consensus statement on MAFLD and the risk of...

Zhou, Xiao-Dong; Targher, Giovanni; Byrne, Christopher D.; Somers, Virend; Kim, Seung Up; Chahal, C. Anwar A.; Wong, Vincent Wai-Sun; Cai, Jingjing

Background: Fatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25-30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies its pathogenesis, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been proposed for this condition. MAFLD is closely intertwined...


Association Between Preexisting Versus Newly Identified Atrial Fibrillation and...

Bikdeli, Behnood; Jiménez, David; del Toro, Jorge; Piazza, Gregory; Rivas, Agustina; Fernández‐Reyes, José Luis; Sampériz, Ángel; Otero, Remedios

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the...


2020 ESC Guidelines for the diagnosis and management of atrial fibrillation dev...

Hindricks, Gerhard; Potpara, Tatjana; Dagres, Nikolaos; Arbelo, Elena; Bax, Jeroen J.; Blomström-Lundqvist, Carina; Boriani, Giuseppe; Castella, Manuel

Atrial fibrillation (AF) poses significant burden to patients, physicians, and healthcare systems globally. Substantial research efforts and resources are being directed towards gaining detailed information about the mechanisms underlying AF, its natural course and effective treatments (see also the ESC Textbook of Cardiovascular Medicine: CardioMed) and new evidence is continuously generated and published. The...


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