3 documents found, page 1 of 1
Molecular characterization of the complement C1q, C2 and C4 genes in Brazilian ...
Liphaus, Bernadete L.; Umetsu, Natalia; Jesus, Adriana A.; Bando, Silvia Y.; Silva, Clovis A.; Carneiro-Sampaio, MagdaOBJECTIVE: To perform a molecular characterization of the C1q, C2 and C4 genes in patients with juvenile systemic lupus erythematosus. METHODS: Patient 1 (P1) had undetectable C1q, patient 2 (P2) and patient 3 (P3) had decreased C2 and patient 4 (P4) had decreased C4 levels. All exons and non-coding regions of the C1q and C2 genes were sequenced. Mononuclear cells were cultured and stimulated with interferon ga...
Increased IgE serum levels are unrelated to allergic and parasitic diseases in ...
Liphaus, Bernadete L.; Jesus, Adriana A.; Silva, Clovis A.; Coutinho, Antonio; Carneiro-Sampaio, MagdaOBJECTIVE: The aim of this study was to assess the IgE serum levels in juvenile systemic lupus erythematosus patients and to evaluate possible associations with clinical and laboratory features, disease activity and tissue damage. METHODS: The IgE serum concentrations in 69 consecutive juvenile systemic lupus erythematosus patients were determined by nephelometry. IgG, IgM and IgA concentrations were measured b...
The role of apoptosis proteins and complement components in the etiopathogenesi...
Liphaus, Bernadete L.; Kiss, Maria Helena BittencourtSystemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is a consensus that accelerated apoptosis of circulating lymphocytes and/or impaired clearance of apoptotic bodies may increase the amount of nuclear antigens presented to T lymphocytes. This proc...