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A Narrative Review of the Role of Transthyretin in Health and Disease
Liz, MA; Coelho, T; Bellotti, V; Fernandez-Arias, MI; Mallaina, P; Obici, LTransthyretin (TTR) is a tetrameric transport protein highly conserved through vertebrate evolution and synthesized in the liver, choroid plexus, and retinal pigment epithelium. TTR transports the thyroid hormone thyroxine and the retinol-binding protein (RBP) bound to retinol (vitamin A). Mutations in TTR are associated with inherited transthyretin amyloidosis (ATTRv), a progressive, debilitating disease that ...
Date: 2020
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Origin: Repositório Aberto da Universidade do Porto