77 documents found, page 1 of 8
Monoolein/phytantriol-enriched lipid-based nanocarriers loaded with resveratrol...
Faria, Maria João Fernandes; Romaguera, Maria; Gonçalves, Hugo Manuel Castro; Ribeiro, Artur; Ribeiro, Clarisse Marta Oliveira; Lira, MadalenaMost topical ophthalmic solutions to treat posterior eye disorders demonstrate low therapeutic bioavailability. This results in poor medical outcomes and underlines the need for innovative non-invasive approaches. In this study, lipid-based nanocarriers (LN) of dioctadecyldimethylammonium bromide (DODAB) enriched with monoolein (MO@LN) or phytantriol (PHY@LN) were loaded with resveratrol (RSV-MO@LN/-PHY@LN) and...
Tear film stability in children: age and sex associations explored through non-...
Silva, Filipe da; Linhares, João M. M.; Jorge, Jorge; Lira, MadalenaPurpose: The stability of the tear film is crucial for maintaining good ocular health. Its assessment provides valuable insights into paediatric eye conditions. This study investigates the stability of the tear film in children and its association with predictive factors such as age and sex, for a better understanding of tear film dynamics in a paediatric population. Methods: A cross-sectional study was conduct...
What intrinsic factors affect the central corneal thickness?
Silva, Filipe da; Linhares, João M. M.; Lira, MadalenaThe cornea is one of the tissues responsible for covering and protecting the inner structures of the eye. Central corneal thickness (CCT) is defined as the distance between the anterior epithelial surface and the posterior surface of the endothelial layer. This parameter plays a very important role regarding intraocular pressure (IOP) measurement, evaluation of corneal uniformity, selection of a suitable techni...
Albumin/Hyaluronic acid nanoparticle-laden contact lenses for the ocular delive...
Senra, Sara F. M.; Veloso, Sérgio Rafael Silva; Lira, Madalena; Castanheira, Elisabete M. S.Nanoparticle-laden contact lenses are a formidable strategy for ocular drug delivery. However, incorporating nanoparticles to achieve sustained drug release without affecting the contact lenses' properties remains a challenging task. In this work, daily and monthly replacement silicone-hydrogel contact lenses laden with bovine serum albumin/hyaluronic acid (BSA/HA) nanoparticles are presented. These nanoparticl...
Eye-LRCN: A long-term recurrent convolutional network for eye blink completenes...
Cruz, Gonzalo de la; Lira, Madalena; Luaces, Oscar; Remeseiro, BeatrizComputer vision syndrome causes vision problems and discomfort mainly due to dry eye. Several studies show that dry eye in computer users is caused by a reduction in the blink rate and an increase in the prevalence of incomplete blinks. In this context, this article introduces Eye-LRCN, a new eye blink detection method that also evaluates the completeness of the blink. The method is based on a long-term recurre...
The influence of the tear film on the intraocular pressure and the corneal biom...
Silva, Filipe da; Linhares, João M. M.; Lira, MadalenaPurpose: As ocular dryness and glaucoma are more prevalent with increasing age, understanding how the tear film affects tonometry is important. The present study aims to understand the impact that changes in the tear film have on intraocular pressure (IOP), corneal hysteresis, and corneal resistance factor measurements. Methods: Cross-sectional research was conducted and 37 patients were assessed. The tear film...
Assessing a novel blink evaluation method: a comprehensive comparison with esta...
Sousa, Fabiana; Cruz, Gonzalo de la; Remeseiro, Beatriz; Luaces, Oscar; Lira, MadalenaPurpose: The primary objective was to evaluate a new developed computer-based method for blink evaluation comparing it to established methodologies to assess its strengths, weaknesses, and utility in clinical settings. We aimed to determine its advantages and limitations and evaluate its potential to enhance existing practices in ocular healthcare. Methods: The study included twenty-four participants (13 female...
Influence of the lens material in daily CLs incorporating drug-loaded Chitosan/...
Vale, Sofia; Veloso, Sérgio Rafael Silva; Lira, Madalena; Castanheira, Elisabete M. S.Purpose: To investigate the behavior of different contact lens materials with incorporated Chitosan/Hyaluronic Acid (Ch/HA) nanoparticles loaded with the anticancer drug methotrexate (MTX). Methods: MTX-loaded nanoparticles were characterized with respect to their size and zeta potential (by Dynamic Light Scattering), stability, drug encapsulation efficiency, drug loading capacity and release profile (using UV/...
Exploring the relationship between tear film stability, digital device usage, a...
Sousa, Fabiana; García Queiruga, Jacobo; Pena Verdeal, Hugo; Lira, MadalenaPurpose: Investigating retinal alterations in the AD mouse model APPNL-F/NL-F compared to wild-type mice using optical coherence tomography (OCT). Methods: A cross-sectional study involved 36 mice per group, evaluated longitudinally at 6, 9, 12, 15, 17, and 20 months using OCT. We analyzed: retinal nerve fiber layer + ganglion cell layer (RNFL+GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer ...
Evidence for commonly used teaching, learning and assessment methods in contact...
Woods, Craig; Naroo, Shehzad; Zeri, Fabrizio; Bakkar, May; Barodawala, Fakhruddin; Evans, Vicki; Fadel, Daddi; Kalikivayi, Lavanya; Lira, MadalenaIntroduction: Evidence based practice is now an important part of healthcare education. The aim of this narrative literature review was to determine what evidence exists on the efficacy of commonly used teaching and learning and assessment methods in the realm of contact lens skills education (CLE) in order to provide insights into best practice. A summary of the global regulation and provision of postgraduate ...