7 documents found, page 1 of 1
Association between blood pressure and angiotensin-converting enzymes activity ...
Gaspar, AR; Andrade, B; Mosca, S; Ferreira-Duarte, M; Teixeira, A; Cosme, D; Albino-Teixeira, A; Ronchi, FA; Leite, AP; Casarini, DE; Areias, JCObjectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Gen...
Impact of physical activity on redox status and nitric oxide bioavailability in...
Leite-Almeida, L; Morato, M; Cosme, D; Afonso, J; Areias, JC; Guerra, A; Caldas, Afonso, A; Albino-Teixeira, A; Sousa, T; Correia-Costa, LNutritional status might contribute to variations induced by physical activity (PA) in redox status biomarkers. We investigated the influence of PA on redox status and nitric oxide (NO) production/metabolism biomarkers in nonoverweight and overweight/obese prepubertal children. We performed a cross-sectional evaluation of 313 children aged 8-9 years (163 nonoverweight, 150 overweight/obese) followed since birth...
Longer duration of obesity is associated with a reduction in urinary angiotensi...
Morato, M; Correia-Costa, L; Sousa, T; Cosme, D; Schaefer, F; Areias, JC; Guerra, A; Afonso, AC; Barros, H; Azevedo, A; Albino-Teixeira, ABackground: We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association. Methods: Cross-sectional evaluation of 305 children aged 8–9 years (160 normal weight, 86 overweight, and...
Oxidative stress and nitric oxide are increased in obese children and correlate...
Correia-Costa, L; Sousa, T; Morato, M; Cosme, D; Afonso, J; Areias, JC; Schaefer, F; Guerra, A; Caldas-Afonso, A; Azevedo, A; Albino-Teixeira, AOxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8-9 years. Anthropo...
Urinary fibrogenic cytokines ET-1 and TGF-beta 1 are associated with urinary an...
Correia-Costa, L; Morato, M; Sousa, T; Cosme, D; Guimaraes, JT; Guerra, A; Schaefer, F; Caldas-Afonso, A; Azevedo, A; Albino-Teixeira, ABACKGROUND:Fibrogenic cytokines are recognized as putative drivers of disease activity and histopathological deterioration in various kidney diseases. We compared urinary transforming growth factor β1 (U-TGF-β1) and endothelin 1 (U-ET-1) levels across body mass index classes and assessed their association with the level of urinary angiotensinogen (U-AGT), a biomarker of intrarenal renin-angiotensin-aldosterone ...
Association of myeloperoxidase levels with cardiometabolic factors and renal fu...
Costa, L; Sousa, T; Morato, M; Cosme, D; Afonso, J; Moura, C; Mota, C; Areias, JC; Guerra, A; Schaefer, F; Afonso, AC; Barros, H; Albino-Teixeira, AINTRODUCTION: Myeloperoxidase (MPO), an enzyme linking obesity and cardiovascular (CV) risk in adults, has rarely been studied in young children and no studies assessed its association with renal function. We sought to explore a possible association between serum MPO levels, obesity, CV risk factors and renal function in prepubertal children. MATERIALS/METHODS: Cross-sectional evaluation of 309 children aged 8-...
Gender and obesity modify the impact of salt intake on blood pressure in children
Correia-Costa, L; Cosme, D; Nogueira-Silva, L; Morato, M; Sousa, T; Moura, C; Mota, C; Guerra, A; Albino-Teixeira, A; Areias, JC; Schaefer, F; Lopes, CBACKGROUND:Most modifiable risk factors for high blood pressure (BP), such as obesity and salt intake, are imprinted in childhood and persist into adulthood. The aim of our study was to evaluate the intake of salt in children and to assess its impact on BP taking into account gender and nutritional status. METHODS:A total of 298 children aged 8-9 years were evaluated in a cross-sectional study. Anthropometric m...