7 documents found, page 1 of 1
Anti-inflammatory effect of the antidepressant fluvoxamine – a systematic review
Ramalho, A.; Carvalho, R.; Barroso, F.; Cruz, A.; Santos, M.Neuroinflammation corresponds to the immune response of the nervous system to an injury, infection or neurodegenerative disease characterized by the activation of resident glial cells, including microglia and astrocytes, the release of cytokines and chemokines and the activation and migration of leukocytes. Evidence suggests that inflammatory cytokines may be a central factor, affecting multiple neuronal pathwa...
The involvement of Nrf2 in depression: systematic review of preclinical studies
Fonseca, D.; Carvalho, R.; Barroso, F.; Cruz, A.; Santos, M.Increased levels of pro-inflammatory cytokines and decreased antioxidant defenses are likely to be linked to the development of depressive symptoms. Nrf2 plays an important role in cellular defense against oxidative stress and binds to ARE, which is located in the promoter region of several phase II antioxidant enzymes and associated stress-responsive enzymes. Reduced Keap1-Nrf2 signaling is implicated in the p...
The Impact of Deceased Donor Maintenance on the Incidence of Delayed Kidney All...
Costa, S.; Barroso, F.; Oliveira, C.; Daher, E.; Fernandes, P.; Andrade, L. [UNESP]; Esmeraldo, R.; Sandes-Freitas, T.Made available in DSpace on 2021-06-25T11:20:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01; Univ Fed Ceara, Fortaleza, Ceara, Brazil; Univ Estadual Paulista, Botucatu, SP, Brazil; Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil; Univ Estadual Paulista, Botucatu, SP, Brazil
Early data on long‐term efficacy and safety of inotersen in patients with hered...
Brannagan, T. H.; Wang, A. K.; Coelho, T.; Waddington Cruz, M.; Polydefkis, M. J.; Dyck, P. J.; Plante‐Bordeneuve, V.; Berk, J. L.; Barroso, F.Background and purpose: Hereditary transthyretin (hATTR) amyloidosis causes progressive polyneuropathy resulting from transthyretin (TTR) amyloid deposition throughout the body, including the peripheral nerves. The efficacy and safety of inotersen, an antisense oligonucleotide inhibitor of TTR protein production, were demonstrated in the pivotal NEURO-TTR study in patients with hATTR polyneuropathy. Here, the l...
How can the land managers and his multi-stakeholder network at the farm level i...
Barroso, F.; Menezes, H.; Pinto-Correia, T.The changing role of agriculture is at the core of transition pathways in many rural areas. Productivism, post-productivism and multifunctionality have been targeted towards a possible conceptualization of the transition happening in rural areas. The factors of change, including productivist and post-productivist trends, are combined in various ways and have gone in quite diverse directions and intensities, in ...
Land Managers’ Heterogeneity in Mediterranean Landscapes - Consistencies and Co...
Barroso, F.; Pinto-Correia, T.European rural landscapes face today several changes, which might indicate that an ongoing transition process is taking place. While these transition processes have been mainly addressed for Western Europe and landscapes dominated by intensive agriculture, they remain to be understood in Southern Europe, where large areas are occupied by extensive farming systems, maintaining a distinctive landscape character. ...
Modelação de organismos com crescimento logarítmico: aplicação às amonites *
Barroso, F.; Kullberg, J. C.; Rocha, R. B.This work refers to the development of modelling tools to create Ammonite shells in order to produce animated models for scientific dissemination and didactic purposes. In the approach here proposed we assume that the growth of those shells from an initial stage – the protoconch – can be interpreted as a succession of revolutions in turn of a central axis; thus the conch’s section will increase as a non-linear ...