5 documents found, page 1 of 1
Development of bioabsorbable polylactide membrane with controllable hydrophilic...
Yang, Yang; Qiu, Xiaofeng; Sun, Yi; Wang, Yifeng; Wang, Jine; Li, Yulin; Liu, ChangshengCell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the h...
Nonionic surfactant-stabilized raspberry-like polymer/silica nanoparticles late...
Chen, Zhaoxia; Zhang, Yuhong; Liu, Yue; Duan, Lanlan; Wang, Zhiguo; Liu, Changsheng; Li, Yulin; He, PeixinRaspberry-like P(St-BA)/SiO2 nanoparticle latexes were prepared via miniemulsion polymerization of styrene (St) and butyl acrylate (BA) in the presence of 20 nm glycerol-modified SiO2 sol as a Pick ering emulsifier and octaphenyl polyoxyethylene (CA-897) as a nonionic surfactant, using 2,2-azobis (isobutyronitrile) (AIBN) as an initiator. 2-(Methacryloyl) ethyltrimethylammonium chloride (MTC) was introduced to ...
Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) na...
Zhan, Yuan; Gonçalves, Mara; Yi, Panpan; Capelo, Débora; Zhang, Yuhong; Rodrigues, João; Liu, Changsheng; Tomás, Helena; Li, Yulin; He, PeixinThe clinical application of doxorubicin (DOX), like other anticancer drugs, is limited by insufficient cellular uptake and the numerous drug resistance mechanisms existing in cells. The development of smart nanomaterials capable of carrying the drugs into the cells and of releasing them under the control of the microenvironment is an interesting approach that may increase the success of the anticancer drugs curre...
pH-sensitive Laponite®/doxorubicin/alginate nanohybrids with improved anticance...
Gonçalves, Mara; Figueira, Priscilla; Maciel, Dina; Rodrigues, João; Qu, Xue; Liu, Changsheng; Tomás, Helena; Li, YulinThe efficacy of the anticancer drug doxorubicin (Dox) is limited by an insufficient cellular uptake and drug resistance, which is partially due to ion trapping in acidic environments such as the extracellular environment of solid tumors and the interior of endolysosome vesicles. Herein, we describe the preparation and in vitro evaluation of a new type of nanohybrid for anticancer drug delivery which is capable ...
Amphiphilic polymer-mediated formation of laponite-based nanohybrids with robus...
Wang, Guoying; Maciel, Dina; Wu, Yilun; Rodrigues, João; Shi, Xiangyang; Yuan, Yuan; Liu, Changsheng; Tomás, Helena; Li, YulinThe development of pH-sensitive drug delivery nanosystems that present a low drug release at the physiological pH and are able to increase the extent of the release at a lower pH value (like those existent in the interstitial space of solid tumors (pH 6.5) and in the intracellular endolysosomal compartments (pH 5.0)) is very important for an efficient and safe cancer therapy. Laponite (LP) is a synthetic silica...