8 documents found, page 1 of 1
Nano-armed Limosilactobacillus reuteri for enhanced photo-immunotherapy and mic...
Xu, Haiting; Wang, Yajun; Liu, Ga; Zhu, Zhenhua; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Shi, Xiaoxiao; Zu, Menghang; Xiao, BoDespite being a groundbreaking approach to treating colorectal cancer (CRC), the efficacy of immunotherapy is significantly compromised by the immunosuppressive tumor microenvironment and dysbiotic intestinal microbiota. Here, leveraging the superior carrying capacity and innate immunity-stimulating property of living bacteria, a nanomedicine-engineered bacterium, LR-S-CD/CpG@LNP, with optical responsiveness, i...
Antheraea pernyi silk nanofibrils with inherent RGD motifs accelerate diabetic ...
Duan, Lian; Liu, Ga; Liao, Fuying; Xie, Chunyu; Shi, Jiahao; Yang, Xiao; Zheng, Fan; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe chronic inflammation and matrix metalloprotease (MMP)-induced tissue degradation significantly disrupt re-epithelization and delay the healing process of diabetic wounds. To address these issues, we produced nanofibrils from Antheraea pernyi (Ap) silk fibers via a facile and green treatment of swelling and shearing. The integrin receptors on the cytomembrane could specifically bind to the Ap nanofibrils (Ap...
Injectable dual-network hydrogel for phototherapy and immunomodulation in the t...
Bao, Shengfei; Jiang, Aodi; Peng, Li; Liao, Fuying; Liu, Ga; Chen, Li; Zhou, Peng; Zhu, Zhen; Reis, R. L.; Kundu, Subhas C; Duan, Lian; Xiao, BoContinuous invasion and infection of drug-resistant bacteria leads to chronic inflammation and ulcers in skin wounds, which hinders wound healing and even results in sepsis. Here, we constructed a multifunctional injectable hydrogel (GA/PIOP/SF) that was composed of a synthesized porous ionic organic polymer (PIOP) with photothermal and photodynamic therapy (PDT/PTT) capacities to kill bacteria, a bioactive sma...
Oral exosome-like nanovesicles from Phellinus linteus suppress metastatic hepat...
Zu, Menghang; Liu, Ga; Chen, Nanxi; Chen, Li; Gao, Qiang; Reis, R. L.; Kundu, Subhas C; Jin, Meilan; Xiao, Bo; Shi, XiaoxiaoThe biomedical application of nanotechnology in cancer treatment has demonstrated significant potential for improving treatment efficiencies and ameliorating adverse effects. However, the medical translation of nanotechnology-based nanomedicines faces challenges including hazardous environmental effects, difficulties in large-scale production, and possible excessive costs. In the present study, we extracted and...
Gas-propelled nanomotors alleviate colitis through the regulation of intestinal...
Xiao, Bo; Liang, Yuqi; Liu, Ga; Wang, Lingshuang; Zhang, Zhan; Qiu, Libin; Xu, Haiting; Carr, Sean; Shi, Xiaoxiao; Reis, R. L.; Kundu, Subhas CThe progression of ulcerative colitis (UC) is associated with immunologic derangement, intestinal hemorrhage, and microbiota imbalance. While traditional medications mainly focus on mitigating inflammation, it remains challenging to address multiple symptoms. Here, a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO2Â nanospheres with Cu2O nanoblocks. The resulting CaO2â Cu...
CaO2-Cu2O micromotors accelerate infected wound healing through antibacterial f...
Liu, Ga; Zu, Menghang; Wang, Lingshuang; Xu, Cheng; Zhang, Jiamei; Reis, R. L.; Kundu, Subhas C; Xiao, Bo; Duan, Lian; Yang, XiaoDuring the wound tissue healing process, the relatively weak driving forces of tissue barriers and concentration gradients lead to a slow and inefficient penetration of bioactive substances into the wound area, consequently showing an impact on the effectiveness of deep wound healing. To overcome these challenges, we constructed biocompatible CaO2–Cu2O “micromotors”. These micromotors reacted with the fluids at...
Extracellular vesicles from nanomedicine-trained intestinal microbiota substitu...
Zu, Menghang; Liu, Ga; Xu, Haiting; Zhu, Zhenhua; Zhen, Junfeng; Shi, Baoyi; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Nie, GuangjunThe biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular vesicles (Gm-EVs), which play a critical role in bacteria-to-bacteria and bacteria-to-host communications. Herein, intestinal microbiota are trained using tea leaf lipid/pluronic F127-coated curcumin nanocrystals (CN@Lp127s),...
Bioinspired polyacrylic acid-based dressing: wet adhesive, self-healing, and mu...
Wang, Lingshuang; Duan, Lian; Liu, Ga; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Kundu, Subhas C; Reis, R. L.; Xiao, Bo; Yang, XiaoPolyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong wet adhesion capability is fabricated through a facile mixture of PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid (TA). The poly(ethylene glycol) segm...