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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signa...
Tullet, Jennifer M. A.; Hertweck, Maren; An, Jae Hyung; Baker, Joseph; Hwang, Ji Yun; Liu, Shu; Oliveira, Riva de Paula; Baumeister, RalfInsulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and longevity, effects that require the IISinhibited FOXO protein DAF-16. The C. elegans transcription factor SKN-1 also defends against oxidative stress bymobilizing the conserved phase 2 detoxification response. Herewe showthat IIS not only oppos...
Date: 2015
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Origin: Oasisbr