2 documents found, page 1 of 1
Analysis of sialyl-Lewis x on MUC5AC and MUC1 mucins in pancreatic cancer tissues
Balmaña, M; Duran, A; Gomes, C; Llop, E; López-Martos, R; Ortiz, MR; Barrabés, S; Reis, CA; Peracaula, RPancreatic adenocarcinoma (PDAC) lacks efficient biomarkers. Mucins are glycoproteins that can carry aberrant glycosylation in cancer. Our objective was to identify cancer-related glycan epitopes on MUC1 and MUC5AC mucins in PDAC as potential biomarkers. We have analysed the tumour-associated carbohydrate antigens sialyl-Lewis x (SLex) and sialyl-Tn (STn) on MUC1 and MUC5AC in PDAC tissues. The selected cohort ...
Latin Americans show wide-spread Converso ancestry and imprint of local Native ...
Chacón-Duque, J; Adhikari, K; Fuentes-Guajardo, M; Mendoza-Revilla, J; Acuña-Alonzo, V; Barquera, R; Quinto-Sánchez, M; Gómez-Valdés, JHistorical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry compo...