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Near-Infrared Light Activated Formulation for the Spatially Controlled Release ...
Simões, Susana; Lino, Miguel; Barrera, Angela; Rebelo, Catarina; Tomatis, Francesca; Vilaça, Andreia; Breunig, Christopher; Neuner, Andrea; Peça, JoãoThe CRISPR/Cas9 system has emerged as a promising platform for gene editing; however, the lack of an efficient and safe delivery system to introduce it into cells continues to hinder clinical translation. Here, we report a rationally designed gene-editing nanoparticle (NP) formulation for brain applications: an sgRNA:Cas9 ribonucleoprotein complex is immobilized on the NP surface by oligonucleotides that are co...
Blood-brain barrier dysfunction in aging is mediated by brain endothelial senes...
Novo, João P.; Gee, Lucy; Caetano, Carolina A; Tomé, Inês; Vilaça, Andreia; von Zglinicki, Thomas; Moreira, Irina S; Jurk, Diana; Rosa, SusanaBBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.; SR acknowledges the...
Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells
Vilaça, Andreia; Jesus, Carlos; Lino, Miguel; Hayman, Danika; Emanueli, Costanza; Terracciano, Cesare M.; Fernandes, Hugo; de Windt, Leon J.CC BY-NC-ND 4.0; The authors would like to acknowledge Crioestaminal (www.crioestaminal.pt) for providing samples and other helpful information and Dr. Yingqun Huang for providing the lncRNA H19 plasmid. The authors would further like to acknowledge the funding by the FCT PhD Studentships (SFRH/BD/119187/2016 & SFRH/BD/ 144092/2019), Programa Operacional Competividade e Internacionalização (POCI) na sua compone...
Remodelling of the cardiac extracellular matrix proteome during chronological a...
Santinha, Deolinda; Vilaça, Andreia; Estronca, Luís; Schüler, Svenja; Bartoli, Catherine; Sandre-Giovannoli, Annachiara De; Figueiredo, Arnaldo
Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers
Lino, Miguel M.; Simões, Susana; Vilaça, Andreia; Antunes, Helena; Zonari, Alessandra; Ferreira, Lino"This document is the unedited Author's version of a Submitted Work that was subsequently accepted for publication in [JournalTitle], copyright © American Chemical Society after peer review. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see https://pubs.acs.org/doi/ipdf/10.1021/acsnano.7b07538; The authors are grateful for the financial...