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Pulmonary Emphysema Regional Distribution and Extent Assessed by Chest Computed...

Gomes, P; Bastos, HN; Carvalho, A; Lobo, A; Guimarães, A; Rodrigues, RS; Zin, WA; Carvalho, ARS

Objective: This study aimed to evaluate how emphysema extent and its regional distribution quantified by chest CT are associated with clinical and functional severity in patients with chronic obstructive pulmonary disease (COPD). Methods/Design: Patients with a post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < 0.70, without any other obstructive airway disease, who ...


Novel Ocellatin Peptides Mitigate LPS-induced ROS Formation and NF-kB Activatio...

Sousa, NA; Oliveira, GAL; Oliveira, AP; Lopes, ALF; Iles, B; Nogueira, KM; Araújo, TSL; Souza, LKM; Araújo, AR; Ramos-Jesus, J; Plácido, A; Amaral, C

Cutaneous secretions of amphibians have bioactive compounds, such as peptides, with potential for biotechnological applications. Therefore, this study aimed to determine the primary structure and investigate peptides obtained from the cutaneous secretions of the amphibian, Leptodactylus vastus, as a source of bioactive molecules. The peptides obtained possessed the amino acid sequences, GVVDILKGAAKDLAGH and GVV...


A brief diagnostic screening instrument for mental disturbances in general medi...

Fink, P; Ørnbøl, E; Huyse, F; Jonge, P; Lobo, A; Herzog, T; Slaets, J; Arolt, V; Cardoso, G; Rigatelli, M; Hansen, M

OBJECTIVE: Mental illness is prevalent among general hospital ward patients but often goes unrecognised. The aim of this study was to validate the SCL-8d as a brief questionnaire for mental disturbances for use in general hospitals. METHODS: The study included 2040 patients, 18 years or older, consecutively admitted to 11 general internal medicine wards in seven European countries. All patients were screened on...


Risk factors for complex care needs in general medical inpatients: results from...

de Jonge, P; Huyse, F; Herzog, T; Lobo, A; Slaets, J; Lyons, J; Opmeer, B; Stein, B; Arolt, V; Balogh, N; Cardoso, G

The authors linked admission risk factors to a series of indicators for complex care delivery to enable detection of patients in need of care coordination at the moment of admission to the general hospital. The authors found 13 risk factors to be predictive of more than one indicator of care complexity. An admission risk screening procedure to detect patients in need of care coordination should focus on these r...


COMPRI--an instrument to detect patients with complex care needs: results from ...

Huyse, F; Jongue, P; Slaets, J; Lobo, A; Herzog, T; Lyons, J; Opmeer, B; Stein, B; Arolt, V; Cardoso, G

The authors developed a screening instrument to detect patients in need of complex care coordination at admission to a general hospital. On the basis of a series of risk factors for care complexity, the authors constructed a short, care complexity prediction instrument (COMPRI) and assessed its qualities. The COMPRI is an easily administered screening instrument that detects patients at risk for complex care ne...


Consultation-Liaison psychiatric service delivery: results from a European study

Huyse, F; Herzog, T; Lobo, A; Malt, U; Opmeer, B; Stein, B; Jonge, P; Dijck, R; Creed, F; Crespo, MD; Cardoso, G

The reported findings of the European Consultation-Liaison Workgroup (ECLW) Collaborative Study describe consultation-liaison service delivery by 56 services from 11 European countries aggregated on a C-L service level. During the period of 1 year (1991), the participants applied a standardized, reliability tested method of patient data collection, and data were collected describing pertinent characteristics of...


Care complexity in the general hospital: results from a European study

de Jonge, P; Huyse, F; Lobo, A; Slaets, J; Herzog, T; Lyons, J; Opmeer, B; Stein, B; Arolt, V; Balogh, N; Cardoso, G

There is increasing pressure to effectively treat patients with complex care needs from the moment of admission to the general hospital. In this study, the authors developed a measurement strategy for hospital-based care complexity. The authors' four-factor model describes the interrelations between complexity indicators, highlighting differences between length of stay (LOS), objective complexity (such as medic...


Mental disturbances and perceived complexity of nursing care in medical inpatie...

Jonge, P; Zomerdijk, M; Huyse, F; Fink, P; Herzog, T; Lobo, A; Slaetz, J; Harolt, V; Balogh, N; Cardoso, G; Rigatelli, M

AIMS AND OBJECTIVES: The relationship between mental disturbances - anxiety and depression, somatization and alcohol abuse - on admission to internal medicine units and perceived complexity of care as indicated by the nurse at discharge was studied. The goal was to study the utility of short screeners for mental disturbances to select patients for case-management on admission. DESIGN: The study had a cohort des...


European consultation-liaison services and their user populations: the European...

Huyse, F; Herzog, T; Lobo, A; Malt, U; Opmeer, B; Stein, B; Cardoso, G

The authors identified variations in the characteristics of patients referred to 56 consultation-liaison (C-L) services in 11 European countries. The authors found differences in the types of patients referred to the services, and there were significant differences between countries. The first difference lays in whether services saw patients for deliberate self-harm and for substance abuse. German psychosomatic...


European Consultation-Liaison Psychiatric Services: the ECLW Collaborative Study

Huyse, F; Herzog, T; Lobo, A; Malt, U; Opmeer, B; Stein, B; Creed, F; Crespo, MD; Cardoso, G; Guimarães-Lopes, R; Mayou, R; van Moffaert, M

OBJECTIVE: To describe the patterns of organization of consultation-liaison (C-L) services in 11 European countries in relation to hospital characteristics and national approaches to C-L psychiatry. METHOD: Cross-sectional survey. RESULTS: Services can best be described in terms of their size and seniority of their staff and whether or not they are multidisciplinary. Single-discipline services are based upon th...


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