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TERT, BRAF and NRAS in primary thyroid cancer and metastatic disease

Melo, M; Gaspar da Rocha, A; Batista, R; Vinagre, J; Martins, MJ; Costa, G; Ribeiro, C; Carilho, F; Leite, V; Lobo, C; Cameselle-Teijeiro, JM

Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype. Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF, and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNMs), and distant metastases. Design and Patients: Mutation analysis was performed in 43...


Evaluation of the efficacy and safety of a standardised intracameral combinatio...

Labetoulle, M; Findl, O; Malecaze, F; Alió, J; Cochener, B; Lobo, C; Lazreg, S; Hartani, D; Colin, J; Tassignon, MJ; Behndig, A

BACKGROUND/AIMS: To compare the efficacy and safety of intracameral (IC) administration at the beginning of cataract surgery, of Mydrane, a standardised ophthalmic combination of tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%, to a standard topical regimen. METHODS: In this international phase III, prospective, randomised study, the selected eye of 555 patients undergoing phacoemulsification with intra...


Quantitative evaluation of visual function 12 months after bilateral implantati...

Marques, JP; Rosa, AM; Quendera, B; Silva, F; Mira, J; Lobo, C; Castelo-Branco, M; Murta, JN

PURPOSE: To quantitatively evaluate visual function 12 months after bilateral implantation of the Physiol FineVision® trifocal intraocular lens (IOL) and to compare these results with those obtained in the first postoperative month. METHODS: In this prospective case series, 20 eyes of 10 consecutive patients were included. Monocular and binocular, uncorrected and corrected visual acuities (distance, near, and i...


Pseudophakic Cystoid Macular Edema

Lobo, C

Cataract surgery is an efficient procedure, and is generally associated with good visual results. Nevertheless, cystoid macular edema (CME) may develop, and this can result in suboptimal postoperative vision. Many factors are considered to contribute to its development, and although the treatment options depend upon the underlying cause of CME, the usual therapeutic approach for prophylaxis and treatment of CME...



Guia prático de doentes medicados com fármacos que interferem na hemostase porp...

Correia, C; Fonseca, C; Lages, N; Lobo, C; Nascimento, A; Pinto, C; Lopes, E; Barros, F; Dores, G; Viana, J; Caseiro, J; Peralta, J; Bismark, J


Hypericum glandulosum 5S ribosomal RNA gene, partial sequence

Carvalho, R; Nobrega, F; Lobo, C; Antunes, T; Sevinate-Pinto, I; Vidal, R; Teixeira, G


Hypericum perforatum 26S ribosomal RNA gene, partial sequence

Carvalho, R; Nobrega, F; Lobo, C; Antunes, T; Sevinate-Pinto, I; Vidal, R; Teixeira, G


Hypericum perforatum 5S ribosomal RNA gene, partial sequence

Carvalho, R; Nobrega, F; Lobo, C; Antunes, T; Sevinate-Pinto, I; Vidal, R; Teixeira, G


Hypericum glandulosum 26S ribosomal RNA gene, partial sequence

Carvalho, R; Nobrega, F; Lobo, C; Antunes, T; Sevinate-Pinto, I; Vidal, R; Teixeira, G


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