22 documents found, page 1 of 3
The Definition of Pharmaceutical Product: A Few Comments
Lobo, José Manuel Sousa.
Estratégia para mascarar o sabor amargo de fármacos em formulações orais pediát...
Pinto, Susana; Gomes, Joana; Ogbonna, John Dike N.; Cunha, Edite; Attama, Anthony A.; Ofokansi, Kenneth C.; Ferreira, Helena; Marx, ÍtalaA facilidade de administração e a possibilidade de ajuste de dose das formas farmacêuticas líquidas para administração oral, reforçam a sua grande utilidade na população pediátrica
Estratégia para mascarar o sabor amargo de fármacos em formulações orais pediát...
Pinto, Susana; Gomes, Joana; Ogbonna, John Dike N.; Cunha, Edite; Attama, Anthony A.; Ofokansi, Kenneth C.; Ferreira, Helena; Marx, ÍtalaO sabor amargo de fármacos constitui uma barreira à adesão terapêutica em pediatria. Existem disponíveis várias estratégias para mascarar o amargor, mas a maioria é de difícil implementação na Farmácia Hospitalar (FH). Desenvolvimento de um veículo para administração oral para uso pediátrico, de composição simples e de fácil preparação, com o objetivo de mascarar o sabor amargo de um fármaco modelo com elevado ...
Portal infoCosméticos: a digital tool to empower consumers and health professio...
Torres, Ana; Fonseca, Leonor; Ferreira, Marta; Silvano, Maria da Purificação; Lobo, José Manuel Sousa; Almeida, Isabel F.Nowadays, the information regarding cosmetic products available to the community is vast, although not always trustworthy. The Pharmaceutical Technology Laboratory of the Faculty of Pharmacy of the University of Porto (FFUP) launched the Portal infoCosméticos aiming to provide professionals involved in cosmetic advice with reliable information, supported by up-to-date scientific evidence, while empowering Portu...
Overcoming challenges in pediatric formulation with a patient-centric design ap...
Ogbonna, John Dike N.; Cunha, Edite; Attama, Anthony A.; Ofokansi, Kenneth C.; Ferreira, Helena; Pinto, Susana; Gomes, Joana; Marx, ÍtalaDesigning oral formulations for children is very challenging, especially considering their peculiarities and preferences. The choice of excipients, dosing volume and palatability are key issues of pediatric oral liquid medicines. The purpose of the present study is to develop an oral pediatric solution of a model bitter drug (ranitidine) following a patient centric design process which includes the definition o...
Design of an Emulgel for Psoriasis Focused on Patient Preferences
Oliveira, Rita Sanches; da Silva, Diva Ferraz; Mota, Sandra; Garrido, Jorge; Garrido, E. Manuela; Lobo, José Manuel Sousa; Almeida, Isabel FilipaAdherence to topical treatments is low and is known to be influenced by the vehicle properties. Betamethasone dipropionate (BD) is an anti-inflammatory steroid, used in psoriasis treatment in the form of an ointment, cream, or solution. The aim of this work was to develop a new vehicle for BD, focusing on the preferences of patients with psoriasis as a strategy to improve treatment adherence. Two vehicles with ...
Preparações oftálmicas – novas estratégias para a promoção da biodisponibilidade
Almeida, Hugo; Silva, Ana Catarina; Amaral, Maria Helena; Lobão, Paulo; Lobo, José Manuel SousaAs preparações oftálmicas apresentam como principal vantagem o facto de poderem ser facilmente administradas pelo paciente. No entanto, estas preparações apresentam várias desvantagens, entre as quais se destaca o tempo de residência diminuto da formulação na superfície do globo ocular, o que condiciona a eficácia do fármaco veiculado. Desta forma, existem diversas estratégias que podem ser adotadas para aument...
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles...
Costa, Cláudia Pina; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana CatarinaThe management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising results. In addition, the encapsulation of the drugs in ...
Application of the Quality-by-Design (QbD) approach to improve the nose-to-brai...
Costa, Cláudia Pina; Cunha, Sara; Peixoto, Andreia F.; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana CatarinaThe intranasal administration of nanostructured lipid carriers (NLCs) has been suggested as a promising strategy to improve the fast treatment of epilepsy. This route allows for drug passage directly from the nose to the brain, avoiding the need of bypassing the blood–brain barrier. In addition, the quality-by-design (QbD) approach is a useful tool for the optimization of manufacturing variables, resulting in e...
Current applications of pharmaceutical biotechnology
Silva, Ana Catarina; Moreira, João Nuno; Lobo, José Manuel Sousa; Almeida, HugoThis book offers an authoritative review of biopharmaceuticals and their clinical relevance. Biopharmaceuticals have been showing high therapeutic potential by means of biological and biosimilar medicines, particularly for the treatment of cancer, chronic diseases (e.g. diabetes, Crohn's disease, psoriasis and rheumatoid arthritis), neurodegenerative disorders (e.g. multiple sclerosis), and they have also been ...