7 documents found, page 1 of 1
Antifungal activity of palmatine against strains of Candida spp. resistant to a...
Campos, Rosana de Sousa; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Sampaio, Letícia Serpa; Nascimento, Francisca Bruna Stefany Aires doThe incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...
Proteomic analysis to identify candidate biomarkers associated with type 1 diab...
Oliveira, Valzimeire do Nascimento de; Lima-Neto, Abelardo Barbosa Moreira; Tilburg, Maurício Fraga van; Monteiro-Moreira, Ana Cristina de OliveiraPurpose: Type 1 diabetes mellitus (DM1) is one of the most common chronic diseases observed during childhood. The incidence of DM1 is increasing worldwide, and there is currently no way to prevent or delay the onset or to cure the disease. Most diseases, including diabetes, stem from abnormalities in the functioning of proteins, and some studies have reported the expression of protein variation to be involved i...
Análise proteômica de plasma de pacientes com câncer de mama utilizando lectina...
Lobo, Marina Duarte PintoLOBO, Marina Duarte Pinto. Análise proteômica de plasma de pacientes com câncer de mama utilizando lectinas vegetais e label-free LC-MSE. 2016. 158 f. Tese (doutorado em bioquímica)- Universidade Federal do Ceará, Fortaleza-CE, 2016.; The breast cancer presents one of the most commonly diagnosed types of cancer among women worldwide and in Brazil, after nonmelanoma skin cancer. It’s a clinically and biologicall...
Effects of piperonal nitro derivatives on candida species : antifungal activity...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Freitas, Daniel DominguesRecently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...
Caracterização bioquímica, biológica e estrutural de uma quitinase recombinante...
Lobo, Marina Duarte PintoChromobacterium violaceum is a Gram-negative, saprophytic, non-pathogenic and free living bacterium. The complete sequencing of its genome has revealed many genes encoding products of biotechnological interest. Among these products are several chitinases. Chitinases, enzymes capable of degrading chitin, an insoluble polymer of β(1,4)-linked N-acetyl-β-D-glucosamine (GlcNAc), are of great biotechnological intere...
Synergistic effect of the flavonoid catechin, quercetin, or epigallocatechin ga...
Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Figueiredo, Narjara Silvestre; Sampaio, Letícia SerpaFlavonoids are a class of phenolic compounds commonly found in fruits, vegetables, grains, flowers, tea, and wine. They differ in their chemical structures and characteristics. Such compounds show various biological functions and have antioxidant, antimicrobial, anti-inflammatory, and antiapoptotic properties. The aim of this study was to evaluate the in vitro interactions of flavonoids with fluconazole against...
Synergistic effects of amiodarone and fluconazole on Candida tropicalis resista...
Silva, Cecília Rocha da; Andrade Neto, João Batista de; Sidrim, José Júlio Costa; Ângelo, Maria Rozzelê Ferreira; Magalhães, Hemerson Iury FerreiraThere have recently been significant increases in the prevalence of systemic invasive fungal infections. However, the number of antifungal drugs on the market is limited in comparison to the number of available antibacterial drugs. This fact, coupled with the increased frequency of cross-resistance, makes it necessary to develop new therapeutic strategies. Combination drug thera- pies have become one of the mos...