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Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis
Santarino, Inês B.; Viegas, Michelle S.; Domingues, Neuza S.; Ribeiro, Ana M.; Soares, Miguel P.; Vieira, Otília V.Erythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors. Here, we report that besides recruitment of microtubule-associated protein-1-light chain 3 (LC3), addi...
Date: 2017
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Origin: ARCA - Access to Research and Communication Annals