4 documents found, page 1 of 1
Polymorphisms within the TNFSF4 and MAPKAPK2 Loci influence the risk of develop...
Sánchez-Maldonado, Jose Manuel; Moñiz-Díez, Ana; ter Horst, Rob; Campa, Daniele; Cabrera-Serrano, Antonio José; Martínez-Bueno, ManuelHere, we assessed whether 36 single nucleotide polymorphisms (SNPs) within the <i>TNFSF4</i> and <i>MAPKAPK2</i> loci influence the risk of developing invasive aspergillosis (IA). We conducted a two-stage case control study including 911 high-risk patients diagnosed with hematological malignancies that were ascertained through the aspBIOmics consortium. The meta-analysis of the discovery and replication populat...
Multiplex PCR based strategy for detection of fungal pathogen DNA in patients w...
Carvalho-Pereira, Joana; Fernandes, Filipa; Araújo, Ricardo; Springer, Jan; Loeffler, Juergen; Buitrago, María José; Pais, Célia; Sampaio, PaulaA new and easy polymerase chain reaction (PCR) multiplex strategy, for the identification of the most common fungal species involved in invasive fungal infections (IFI) was developed in this work. Two panels with species-specific markers were designed, the <i>Candida Panel</i> for the identification of <i>Candida</i> species, and the <i>Filamentous Fungi Panel</i> for the identification of <i>Aspergillus</i> sp...
Antifungal-resistant mucorales in different indoor environments
Aranha Caetano, Liliana; Faria, Tiago; Springer, Jan; Loeffler, Juergen; Viegas, CarlaThis paper sought to address the prevalence of Mucorales in different indoor environments in Portugal. Environmental samples (183 in total) were collected at dwellings (n = 79) and workplaces (bakeries, swine farms, taxis, waste-sorting plants) (n = 93) by passive sampling using electrostatic dust collector (EDC), air-conditioning filters, litter, and/or raw materials. Samples were inoculated onto non-selective...
Mucorales prevalence and azole-resistance surveillance on different indoor envi...
Viegas, Carla; Faria, Tiago; Caetano, Liliana Aranha; Loeffler, Juergen; Springer, JanAim of the study - Mucorales species can cause severe infections among immunocompromised patients. Mucormycosis is associated with a great deal of morbidity and infections caused by Mucorales species among patients receiving triazole prophylaxis. Considering the clinical relevance of Mucorales order, the prevalence of these fungal species and azole-resistance surveillance should be ensured in fungal exposure as...