2 documents found, page 1 of 1
A Histone Deacetylase (HDAC) inhibitor with pleiotropic in vitro anti-toxoplasm...
Jublot, Delphine; Cavaillès, Pierre; Kamche, Salima; Francisco, Denise; Fontinha, Diana; Prudêncio, Miguel; Guichou, Jean-Francois; Labesse, GillesToxoplasmosis is a highly prevalent human disease, and virulent strains of this parasite emerge from wild biotopes. Here, we report on the potential of a histone deacetylase (HDAC) inhibitor we previously synthesized, named JF363, to act in vitro against a large panel of Toxoplasma strains, as well as against the liver and blood stages of Plasmodium parasites, the causative agents of malaria. In vivo administra...
INsPECT, an open-source and versatile software for automated quantification of ...
Yazdanparast, Ehsan; Dos Anjos, António; Garcia, Deborah; Loeuillet, Corinne; Shahbazkia, Hamid R.; Vergnes, BaptisteIntracellular protozoan parasites are causative agents of infectious diseases that constitute major health problems for developing countries. Leishmania sp., Trypanosoma cruzi or Toxoplasma gondii are all obligate intracellular protozoan parasites that reside and multiply within the host cells of mammals, including humans. Following up intracellular parasite proliferation is therefore an essential and a quotidi...