15 documents found, page 1 of 2
Investigation of the Chemiluminescent Reaction of a Fluorinated Analog of Marin...
Magalhaes, CM; da Silva, JCGE; da Silva, LPBioluminescence (BL) and chemiluminescence (CL) are remarkable processes in which light is emitted due to (bio)chemical reactions. These reactions have attracted significant attention for various applications, such as biosensing, bioimaging, and biomedicine. Some of the most relevant and well-studied BL/CL systems are that of marine imidazopyrazine-based compounds, among which Coelenterazine is a prime example....
Comparative investigation into the anticancer activity of analogs of marine coe...
Magalhaes, CM; Pereira, RB; Erbiai, E; González Berdullas, P; Joaquim C G E Esteves da Silva; Pereira, DM; da Silva, LPCancer is still one of the most challenging diseases to treat, making the pursuit for novel molecules with potential anticancer activity an important research topic. Herein, we have performed a comparative investigation into the anticancer activity of analogs of marine coelenterazine and coelenteramine. The former is a well-known bioluminescent substrate, while the latter is a metabolic product of the resulting...
Polyfluoroalkyl Substances (PFASs) Detection Via Carbon Dots: A Review
Sendao, RMS; Joaquim C G E Esteves da Silva; da Silva, LPPFASs are a class of highly persistent chemicals that are slowly infiltrating soils and waterways. Thus, there is a great need for fast, sensitive, and reliable techniques to detect PFASs. Conventional methods, such as LC-MS/SPE, allow high sensitivities. However, such methods can be complex and expensive. Considering this, it is not surprising that the scientific community has turned their attention to the sea...
Synchrotron-based FTIR evaluation of biochemical changes in cancer and noncance...
Magalhaes, CM; Ducic, T; Pereira, RB; Gonzalez-Berdullas, P; Rodriguez Borges, JE; Pereira, DM; Joaquim C G E Esteves da Silva; Algarra, M; da Silva, LPThe mode of action toward gastric cancer cells of brominated Coelenteramine, an analogue of a metabolic product of a marine bioluminescent reaction, was investigated by synchrotron radiation-based Fourier Transform Infrared spectrocopy (FTIR). This method revealed that the anticancer activity of brominated Coelenteramine is closely connected with cellular lipids, by affecting their organization and composition....
Investigation of the Superoxide Anion-Triggered Chemiluminescence of Coelentera...
Erbiai, E; Gonzalez-Berdullas, P; Joaquim C G E Esteves da Silva; da Silva, LPReactive oxygen species (ROS), including superoxide anion, are involved in regulating various signaling pathways and are also responsible for oxidative stress. Sensing superoxide anion is of particular importance due to its biological significance. One potential approach is to use Coelenterazine as a chemiluminescent probe for the dynamic sensing of this ROS. In this study, we investigated the superoxide anion-...
Rationalizing the role of electron/charge transfer in the intramolecular chemie...
da Silva, LP; da Silva, JEThe thermolysis of dioxetanones is a key process in the intramolecular chemiexcitation step of several chemi-and bioluminescent reactions. This step is generally explained with mechanisms based on either electron transfer (ET), such as the Chemically Initiated Electron-Exchange Luminescence (CIEEL) mechanism, or charge transfer (CT), such as the Charge Transfer-Initiated Luminescence (CTIL) mechanism. Here, we ...
Combined Experimental and Theoretical Investigation into the Photophysical Prop...
Afonso, ACP; Gonzalez-Berdullas, P; Joaquim C G E Esteves da Silva; da Silva, LPMarine Coelenterazine is one of the most well-known chemi-/bioluminescent systems, and in which reaction the chemi-/bioluminophore (Coelenteramide) is generated and chemiexcited to singlet excited states (leading to light emission). Recent studies have shown that the bromination of compounds associated with the marine Coelenterazine system can provide them with new properties, such as anticancer activity and en...
Investigation of the Anticancer and Drug Combination Potential of Brominated Co...
Magalhaes, CM; Gonzalez-Berdullas, P; Pereira, M; Duarte, D; Nuno Vale; Joaquim C G E Esteves da Silva; da Silva, LPCancer is a very challenging disease to treat, both in terms of therapeutic efficiency and harmful side effects, which continues to motivate the pursuit for novel molecules with potential anticancer activity. Herein, we have designed, synthesized, and evaluated the cytotoxicity of different brominated coelenteramines, which are metabolic products and synthesis precursors of the chemi-/bioluminescent system of m...
Revisiting the Absorption Spectra of Polycyclic Aromatic Hydrocarbons over Port...
Fernandes, GM; Macedo, FJD; Joaquim C G E Esteves da Silva; da Silva, LP<jats:p>Brown carbon is a type of strong light-absorbing carbonaceous aerosol associated with radiative forcing. Nevertheless, the difficulty in correlating the chemical composition of brown carbon with its light absorption properties impairs the proper elucidation of its role in radiative forcing. Here, we have used a time-dependent density functional theory (TD-DFT)-based procedure to revisit the real-world a...
Validation of Spent Coffee Grounds as Precursors for the Development of Sustain...
Crista, DMA; Joaquim C G E Esteves da Silva; da Silva, LP<jats:p>Carbon dots (CDs) are fluorescence carbon-based nanomaterials that possess several properties such as photoluminescence, biocompatibility and good water solubility. They can be fabricated from a large variety of precursors; however, most available organic molecules are still expensive and their use or synthesis can lead to significant challenges to the environment and human health. It has become desirab...