91 documents found, page 1 of 10
Diaphragmatic hernia repair porcine model to compare the performance of biodegr...
Scuglia, Marianna; Frazão, Laura P.; Miranda, Alice Augusta Macedo; Martins, Albino; Barbosa-Sequeira, Joana; Coimbra, Diana; Longatto, AdhemarBackground Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods Twelve male pigs were randomly assigned to 3 diferent groups of 4 an...
Interleukin-8 and Interleukin-6 are biomarkers of poor prognosis in Esophageal ...
Pastrez, Paula Roberta Aguiar; Barbosa, Ana Margarida; Mariano, Vânia Sammartino; Causin, Rhafaela Lima; Castro, António G.; Torrado, EgídioEsophageal squamous cell carcinoma (ESCC) is a common type of cancer characterized by fast progression and high mortality rates, which generally implies a poor prognosis at time of diagnosis. Intricate interaction networks of cytokines produced by resident and inflammatory cells in the tumor microenvironment play crucial roles in ESCC development and metastasis, thus influencing therapy efficiency. As such, cyt...
The usefulness of an Online Simplified Screening Questionnaire (SSQ) in identif...
Vazquez, Fabiana L.; Silveira, Henrique C. S.; Otero, Ubirani B.; Hosokawa, Thais T.; Fregnani, José Humberto T. G.; Longatto, Adhemar; Reis, R. M.To obtain a history of occupational exposure in the workplace, the questionnaire is one of the main sources of information. The aim of this study was to develop an online questionnaire using the REDCap data management platform based on the Work-Related Cancer Surveillance Guidelines, reported by the Brazilian National Cancer Institute. Several issues were taken into consideration for its routine application. It...
Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple...
Ferreira, Débora Carina Gonçalves Abreu; Pereira, Cátia Sofia Santos; Costa, Marta; Afonso, Julieta Alexandra Pereira; Yang, Sujuan; Hensel, JanineTriple negative breast cancer (TNBC) is a highly heterogenous disease not sensitive to endocrine or HER2 therapy and standardized treatment regimens are still missing. Therefore, development of novel TNBC treatment approaches is of utmost relevance. Herein, the potential of MAPK/ERK downregulation by RNAi-based therapeutics in a panel of mesenchymal stem-like TNBC cell lines was uncovered. Our data revealed tha...
Exploring the diversity of visceral, subcutaneous and perivascular adipose tiss...
Ferreira, Joana; Afonso, Julieta Alexandra Pereira; Carneiro, Alexandre Lima; Vila, Isabel; Cunha, Cristina; Roque, Susana; Silva, CristinaThe prevalence of obesity has doubled, with a concomitant increase in cardiovascular disease. This study aimed to compare the characteristics of visceral, subcutaneous and peri-aortic adipose tissue determined with computed tomography (CT) scans and to correlate them with cardiovascular risk factors, anthropometric measures and medication. An observational and prospective study was conducted, and 177 subjects w...
Exosome-mediated MEK1 silencing is a promising approach against triple negative...
Ferreira, Débora; Cátia S. Pereira; Costa, Marta; Afonso, Julieta; Longatto, Adhemar; Baltazar, Fátima; Kalluri, Raghu; Moreira, João N.[Excerpt] Introduction: Breast cancer is a major public health problem worldwide being the most diagnosed cancer in women [1] . Triple negative breast cancer (TNBC) represents 10-20% of all breast cancers and is characterized by the absence of hormone receptors (progesterone and estrogen) and lack of expression of epidermal growth factor receptor 2. Furthermore, it is also described to have poor prognosis due t...
Management of early-stage cervical cancer: a literature review
Guimarães, Yasmin Medeiros; Godoy, Luani Rezende; Longatto, Adhemar; Reis, Ricardo dosCervical cancer (CC) remains a public health issue worldwide despite preventive measures. Surgical treatment in the early-stage CC has evolved during the last decades. Our aim was to review the advances in the literature and summarize the ongoing studies on this topic. To this end, we conducted a literature review through PubMed focusing on English-language articles on the surgical management of early-stage CC....
Management of early-stage vulvar cancer
Pedrão, Priscila Grecca; Guimarães, Yasmin Medeiros; Godoy, Luani Rezende; Possati-Resende, Júlio César; Bovo, Adriane CristinaVulvar cancer is a rare gynecological malignancy since it represents 4% of all cancers of the female genital tract. The most common histological type is squamous cell carcinoma (90%). This type can be classified into two clinicopathological subtypes according to the etiology. The first subtype is associated with persistent human papillomavirus infection and is usually diagnosed in younger women. The second subt...
Is obesity a risk factor for carotid atherosclerotic disease?—opportunistic review
Ferreira, Joana; Cunha, Pedro; Carneiro, Alexandre; Vila, Isabel; Cunha, Cristina; Silva, Cristina; Longatto, Adhemar; Mesquita, Amílcar; Cotter, JorgeObesity is a risk factor for coronary atherosclerosis. However, the influence of adipose tissue in carotid atherosclerosis is not completely understood. No systematic review/meta-analysis was previously performed to understand if obesity is a risk factor for carotid atherosclerosis. This paper aims to provide an opportunistic review of the association between obesity and carotid atherosclerosis and define the r...
Implementation of HPV tests in Latin America: what we learned; what should we h...
Godoy, Luani Rezende; Possati-Resende, Júlio César; Guimarães, Yasmin Medeiros; Pedrão, Priscila Grecca; Reis, Ricardo dos; Longatto, AdhemarCervical cancer is caused by HPV. Although it is the fourth most common type of cancer diagnosed and the fourth cause of cancer death, cervical cancer is nearly completely preventable because of the vaccination and screening available. The present review aims to map the initiatives conducted to implement or evaluate the implementation of HPV testing in Latin American countries. We performed the review by search...