125 documents found, page 1 of 13
The relation of HPV infection and expression of p53 and p16 proteins in esophag...
Pastrez, Paula Roberta Aguiar; Mariano, Vânia Sammartino; Costa, Allini Mafra da; Silva, Estela Maria; Scapulatempo-Neto, CristovamGOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC). RESULTS: High-risk HPV (hr-HPV) wa...
Local and systemic immunomodulatory mechanisms triggered by Human Papillomaviru...
Alvarez, Karla Lucia Fernandez; Beldi, Mariana Carmezim; Sarmanho, Fabiane; Rossetti, Renata Ariza Marques; Silveira, Caio Raony FarinaCervical cancer is the last stage of a series of molecular and cellular alterations initiated with Human Papillomavirus (HPV) infection. The process involves immune responses and evasion mechanisms, which culminates with tolerance toward tumor antigens. Our objective was to understand local and systemic changes in the interactions between HPV associated cervical lesions and the immune system as lesions progress...
The role of liquid based cytology and ancillary techniques in the peritoneal wa...
Rossi, Esther; Bizzarro, Tommaso; Martini, Maurizio; Longatto Filho, Adhemar; Schmitt, Fernando; Fagotti, Anna; Scambia, Giovanni; Zannoni, Gian FrancoBackground The cytological analysis of peritoneal effusions serves as a diagnostic and prognostic aid for either primary or metastatic diseases. Among the different cytological preparations, liquid based cytology (LBC) represents a feasible and reliable method ensuring also the application of ancillary techniques (i.e immunocytochemistry-ICC and molecular testing). Methods We recorded 10348 LBC peritoneal effus...
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High...
Kuil, Larissa de Melo; Lorenzi, Adriana Tarla; Stein, Maíra Degiovani; Resende, Júlio César Possati; Antoniazzi, Márcio; Longatto Filho, AdhemarThe Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia; Objective: To compare the results of cervical cytology and high-risk HPV tests using samples obtained using two different collection modalities in a population of Brazilian women: self-collection (vaginal lavage) and cervical Pap testing. Methods: We enrolled 204 women who were aged 18-64 years and h...
HPV infection and p53 and p16 expression in esophageal cancer: are they prognos...
Costa, Allini Mafra da; Fregnani, José Humberto Tavares Guerreiro; Pastrez, Paula Roberta Aguiar; Mariano, Vânia Sammartino; Silva, Estela MariaBackground: Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic risk factors, alcohol and tobacco, but this hypothesis still remains contradictory. We sought to investigate wether HPV and well-known biomarkers (p16 and p53) and patient-related factors that...
High systemic IL-6 is associated with worse prognosis in patients with non-smal...
Silva, Estela Maria; Mariano, Vânia Sammartino; Pastrez, Paula Roberta Aguiar; Pinto, Miguel Cordoba; Castro, António G.; Syrjanen, Kari JuhaniCharacteristic cytokine patterns have been described in different cancer patients and they are related to their diagnosis, prognosis, prediction of treatment responses and survival. A panel of cytokines was evaluated in the plasma of non-small cell lung cancer (NSCLC) patients and healthy controls to investigate their profile and relationship with clinical characteristics and overall survival. The case-controll...
Somatic mutations in solid tumors: a spectrum at the service of diagnostic arma...
Rossi, Esther Diana; Martini, Maurizio; Bizzarro, Tommazzo; Schmitt, Fernando; Longatto Filho, Adhemar; Larocca, Luigi MariaThis review article deals with the analysis and the detection of the morphological features associated with somatic mutations, mostly BRAF(V600E) mutation, on both cytological and histological samples of carcinomas. Few authors demonstrated that some architectural and specific cellular findings (i.e. polygonal eosinophilic cells defined as "plump cells" and sickle-shaped nuclei) are able to predict BRAF (V600E)...
Molecular diagnosis of infectious diseases using cytological specimens
Canberk, Sule; Longatto Filho, Adhemar; Schmitt, FernandoPathologists have an important role in the diagnosis of infectious disease (ID). In many cases, a definitive diagnosis can be made using cytopathology alone. However, several ancillary techniques can be used on cytological material to reach a specific diagnosis by identifying the causative agent and consequently defining the management of the patient. This review aims to present the effectiveness of the applica...
Prognostic significance of monocarboxylate transporter expression in oral cavit...
Sousa, Susana; Granja, Sara Costa; Pinheiro, Céline; Fernandes, Daniela; Longatto Filho, Adhemar; Laus, Ana Carolina; Alves, Cira Danielle CasadoBackground: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer. The majority of patients present advanced stage disease and has poor survival. Therefore, it is imperative to search for new biomarkers and new alternative and effective treatment options. Most cancer cells rely on aerobic glycolysis to generate energy and metabolic intermediates. This phenotype is a hallmark of c...
Predictor variables and screening protocol for depressive and anxiety disorders...
Lima, Manuela Polidoro; Longatto Filho, Adhemar; Osório, Flávia L.Background Cancer patients are at increased risk of persistent depressive and anxiety symptoms and disorders compared to the general population. However, these issues are not always identified, which may worsen the prognosis and increase morbidity and mortality. Therefore, the objectives of this study are to identify predictor variables (demographic and clinical) for the development of mood and anxiety disorder...