15 documents found, page 1 of 2

In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therap...

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance. Considering that chromene-based scaffolds proved to be attractive candidates for cancer therapy, herein we prepared new chromeno[2,3-d]pyrimidinone derivatives by a simple two step procedure, sta...

Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogram...

Advanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidated. This work aimed to study the metabolic profile of advanced UBC, in the context of cisplatin resistance. Three isogenic pairs of parental cell lines (T24, HT1376 and KU1919)...

Glucose metabolism reprogramming in bladder cancer: hexokinase 2 (HK2) as progn...

Proliferating cancer cells are able to reprogram their energy metabolism, favouring glycolysis even in the presence of oxygen and fully functioning mitochondria. Research is needed to validate the glycolysis-related proteins as prognostic/predictive biomarkers in urothelial bladder carcinoma (UBC), a malignancy tagged by high recurrence rates and poor response to chemotherapy. Here, we assessed GLUT1, HK2, PFKL...

Impact of inflammation on chronic limb-threatening ischaemia

INTRODUCTION: Peripheral arterial disease (PAD) affects more than 202 million people worldwide, 1.3% of which with chronic limb-threatening ischaemia (CLTI). PAD is associated with an elevated mortality and morbidity. However, the evolution from claudication or from asymptomatic PAD to CLTI is not completely understood and cardiovascular risk factors are unable to fully explain it. The aim of this opportunistic...

Frequency of Human Papillomavirus Detection in Chagasic Megaesophagus Associate...

Made available in DSpace on 2022-04-29T08:35:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Background: Chagasic megaesophagus (CM) as well as the presence of human papillomavirus (HPV) has been reported as etiological factors for esophageal squamous cell carcinoma (ESCC). Objective: We assessed the prevalence of HPV DNA in a series of ESCCs associated or not with CM. Data obtained were furthe...

Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gast...

Made available in DSpace on 2020-12-10T16:35:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-01; Portuguese Science and Technology Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tu...

Diversity of human papillomavirus typing among women population living in rural...

PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated ...

Made available in DSpace on 2019-10-06T16:11:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-29; Background: Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. Objective: We analyzed hotspot PIK3CA gene mutations in a series...

HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: ...

Made available in DSpace on 2018-11-26T15:43:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01; FINEP, Brazil; project ON.2 SR&-TD Integrated Program - Programa Operacional Regional do Norte (ON.2-O Novo Norte), Quadro de Referencia Estrategico Nacional (QREN), through Fundo Europeu de Desenvolvimento Regional (FEDER); Fundacao para a Ciencia e Tecnologia (FCT), Portugal; Fundação de Amparo à Pesq...

Targeting lactate transport suppresses in vivo breast tumour growth

Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we have described...