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Selective impact of Tau loss on nociceptive primary afferents and pain sensation

Sotiropoulos, I.; Lopes, André T.; Pinto, Vítor; Lopes, Sofia; Carlos, Sara; Silva, Sara Carina Duarte; Carvalho, Andreia Alexandra Neves de

Tau protein hyperphosphorylation and consequent malfunction are hallmarks of Alzheimer's disease pathology; importantly, pain perception is diminished in these patients. In physiological conditions, Tau contributes to cytoskeletal dynamics and in this way, influences a number of cellular mechanisms including axonal trafficking, myelination and synaptic plasticity, processes that are also implicated in pain perc...

Date: 2014   |   Origin: RepositóriUM - Universidade do Minho
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