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Transthyretin interacts with actin regulators in a Drosophila model of familial...
Silva, MIO; Lopes, CS; Liz, MAFamilial amyloid polyneuropathy (FAP) is a neurodegenerative disorder whose major hallmark is the deposition of mutated transthyretin (TTR) in the form of amyloid fibrils in the peripheral nervous system (PNS). The exposure of PNS axons to extracellular TTR deposits leads to an axonopathy that culminates in neuronal death. However, the molecular mechanisms underlying TTR-induced neurodegeneration are still uncl...
Root causes and outcomes of postoperative pulmonary complications after abdomin...
Fernandes, A; Rodrigues, J; Lages, P; Lanca, S; Mendes, P; Antunes, L; Santos, CS; Castro, C; Costa, RS; Lopes, CS; da Costa, PM; Santos, LLBackground: Postoperative pulmonary complications (PPCs) contribute significantly to overall postoperative morbidity and mortality. In abdominal surgery, PPCs remain frequent. The study aimed to analyze the profile and outcomes of PPCs in patients submitted to abdominal surgery and admitted in a Portuguese polyvalent intensive care unit. Methods: From January to December 2017 in the polyvalent intensive care un...
A toggle-switch and a feed-forward loop engage in the control of the Drosophila...
Sánchez-Aragón, M; Cantisán-Gómez, J; Luque, C; Brás-Pereira, C; Lopes, CS; Lemos, M; Casares, FDipterans show a striking range of eye sizes, shapes, and functional specializations. Their eye is of the compound type, the most frequent eye architecture in nature. The development of this compound eye has been most studied in Drosophila melanogaster. The early development of the Drosophila eye is under the control of a gene regulatory network of transcription factors and signaling molecules called the retina...