12 documents found, page 1 of 2
Natural compounds: co-delivery strategies with chemotherapeutic agents or nucle...
Teixeira, Patrícia V.; Fernandes, Eduarda; Soares, Telma B.; Adega, Filomena; Lopes, Carla M.; Lúcio, M.Cancer is one of the leading causes of death, and latest predictions indicate that cancer- related deaths will increase over the next few decades. Despite significant advances in conventional therapies, treatments remain far from ideal due to limitations such as lack of selectivity, non-specific distribution, and multidrug resistance. Current research is focusing on the development of several strategies to impr...
pH-responsive hybrid nanoassemblies for cancer treatment: formulation developme...
Teixeira, Patrícia V.; Adega, Filomena; Martins-Lopes, Paula; Machado, Raul; Lopes, Carla M.; Lúcio, M.Current needs for increased drug delivery carrier efficacy and specificity in cancer necessitate the adoption of intelligent materials that respond to environmental stimuli. Therefore, we developed and optimized pH-triggered drug delivery nanoassemblies that exhibit an increased release of doxorubicin (DOX) in acidic conditions typical of cancer tissues and endosomal vesicles (pH 5.5) while exhibiting significa...
Nanostructured lipid carriers enriched hydrogels for skin topical administratio...
Lúcio, M.; Giannino, Nicole; Barreira, Sérgio; Catita, José; Gonçalves, Hugo; Ribeiro, Artur; Fernandes, Eduarda; Carvalho, Isabel; Pinho, HugoChronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (ω3) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that lim...
Omega-3- and resveratrol-loaded lipid nanosystems for potential use as topical ...
Caldas, Ana R.; Catita, José; Machado, Raul; Ribeiro, Artur; Cerqueira, Fátima; Horta, Bruno; Medeiros, Rui; Lúcio, Marlene; Lopes, Carla M.Resveratrol (RSV) and omega 3 (!3), because of their biological favorable properties, have become subjects of interest for researchers in dermocosmetic and pharmaceutical industries; however, these bioactives present technological limitations that hinder their effective delivery to the target skin layer. To overcome the stability and skin permeation limitations of free bioactives, this work proposes a combined ...
Lipid nanocarriers for anti-HIV therapeutics: a focus on physicochemical proper...
Faria, Maria J.; Lopes, Carla M.; Neves, José das; Lúcio, M.Since HIV was first identified, and in a relatively short period of time, AIDS has become one of the most devastating infectious diseases of the 21st century. Classical antiretroviral therapies were a major step forward in disease treatment options, significantly improving the survival rates of HIV-infected individuals. Even though these therapies have greatly improved HIV clinical outcomes, antiretrovirals (AR...
Avobenzone-loaded and omega-3-enriched lipid formulations for production of UV ...
Caldas, Ana R.; Faria, Maria J.; Ribeiro, Artur; Machado, Raul; Gonçalves, Hugo; Gomes, Andreia C; Soares, Graça M. B.; Lopes, Carla M.; Lúcio, MarleneGiven the growing harmful effects of ultraviolet (UV) radiation there is an urgent need to develop effective strategies to prevent skin damages. Therefore, hydrogel or cotton and wool fabrics were impregnated with avobenzone (AVO)-loaded and omega-3 (3)-enriched lipid formulations (liposomes LIP, nanostructured lipid carriers NLC and solid lipid nanoparticles SLN) to obtain UV blocking sunscreen gel or function...
Incorporation of lipid nanosystems containing omega‑3 fatty acids and resveratr...
Silva, Juliana; Mesquita, Rui; Pinho, Eva Patrícia Paiva Santos; Caldas, Ana; Real Oliveira, M. Elisabete C.D.; Lopes, Carla M.; Lúcio, MarleneIn the present work, lipid nanosystems containing omega-3 fatty acid (nanostructured lipid carriers, NLCs) or omega-3 fatty acid and resveratrol (liposomes) were developed to improve cotton textile substrates as dressings with anti-inflammatory properties for wound healing applications. Lipid nanosystems were incorporated into woven, non-woven and knitted cotton substrates by exhaustion and impregnation. Based ...
Lipid-based colloidal carriers for topical application of antiviral drugs
Lopes, Carla M.; Silva, Juliana; Lúcio, M.; Real Oliveira, M. Elisabete C.D.Herpes infections are very frequent infectious diseases, especially in individuals whose immune system is weakened, causing manifestations in the central nervous system that leave severe squeals in about 80% of cases. There are several types of etiologic agents of herpes infections, being the most well-known the Herpes Simplex Virus HSV 1 and 2. HSV 1 usually affects the face, lips, gums, palate, tongue and nas...
A systematic review and critical analysis of the role of graphene-based nanomat...
Viseu, T. M. R.; Lopes, Carla M.; Fernandes, Eduarda; Real Oliveira, M. Elisabete C.D.; Lúcio, M.Many graphene-based materials (GBNs) applied to therapy and diagnostics (theranostics) in cancer have been developed. Most of them are hybrid combinations of graphene with other components (e.g., drugs or other bioactives, polymers, and nanoparticles) aiming toward a synergic theranostic effect. However, the role of graphene in each of these hybrids is sometimes not clear enough and the synergic graphene effect...
A molecular biophysical approach to diclofenac topical gastrointestinal damage
Fernandes, Eduarda; Soares, Telma B.; Gonçalves, Hugo; Bernstorff, Sigrid; Real Oliveira, M. Elisabete C.D.; Lopes, Carla M.; Lúcio, M.Diclofenac (DCF), the most widely consumed non-steroidal anti-inflammatory drug (NSAID) worldwide, is associated with adverse typical effects, including gastrointestinal (GI) complications. The present study aims to better understand the topical toxicity induced by DCF using membrane models that mimic the physiological, biophysical, and chemical environments of GI mucosa segments. For this purpose, phospholipid...