88 documents found, page 1 of 9

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Grapevine as a natural resource in the cosmetic industry

Lopes, Carla Martins; Lúcio, Marlene; Oliveira, Rita; Almeida, Isabel; Amaral, M. Helena



Silver nanoparticles for the management of neurological diseases

Teixeira, Maria Inês; Lopes, Carla Martins; Amaral, Maria Helena; Costa, Paulo C.


Tecnologia Farmacêutica I - manual pedagógico das aulas prático-laboratoriais e...

Lopes, Carla Martins

Explicação teórico-prática dos trabalhos PL e protocolos laboratoriais.



Acne vulgaris topical therapies: application of probiotics as a new prevention ...

Dapkevicius, Ieva; Romualdo, Vânia; Marques, Ana Camila; Lopes, Carla Martins; Amaral, Maria Helena

The skin microbiome is an essential barrier for preventing the invasion of pathogens and regulating the immune responses. When this barrier is disrupted, several dermatoses, including acne vulgaris, may arise. Most people will experience acne starting at the onset of puberty and continuing into adolescence; a significant percentage of those individuals continue to suffer from it into adulthood. Although common,...


Natural compounds: co-delivery strategies with chemotherapeutic agents or nucle...

Teixeira, Patrícia V.; Fernandes, Eduarda; Soares, Telma B.; Adega, Filomena; Lopes, Carla Martins; Lúcio, Marlene

Cancer is one of the leading causes of death, and latest predictions indicate that cancer- related deaths will increase over the next few decades. Despite significant advances in conventional therapies, treatments remain far from ideal due to limitations such as lack of selectivity, non-specific distribution, and multidrug resistance. Current research is focusing on the development of several strategies to impr...


Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB):...

Teixeira, Maria Inês; Lopes, Carla Martins; Amaral, Maria Helena; Costa, Paulo C.

The blood-brain barrier (BBB) restricts the access of therapeutic agents to the brain, complicating the treatment of neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), glioma, etc. To overcome this limitation and improve drug delivery to the central nervous system (CNS), the potential of nanocarriers, including lipid-based nanosystems, has been explored. ...


Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Funct...

Teixeira, Maria Inês; Lopes, Carla Martins; Gonçalves, Hugo; Catita, José; Silva, Ana Margarida; Rodrigues, Francisca; Amaral, Maria Helena

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the brain. To overcome these limitations and increase brain targeting, riluzole-loaded nanostructured lipid carriers (NL...


Personalised esomeprazole and ondansetron 3D printing formulations in Hospital ...

Ferreira, Mariana; Lopes, Carla Martins; Gonçalves, Hugo; Pinto, João F.; Catita, José

Individualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is one method for achieving customised medicine in paediatrics. In this work, pre-formulation studies were conducted to evaluate the viability of using specific raw materials to pr...


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