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Klotho in cancer: potential diagnostic and prognostic applications

Mota, J; Lima, AMM; Souza de Andrade, M; Brito, HO; Silva, MMAL; Faustino-Rocha, Ana; Oliveira, PA; Lopes, FF; Gil da Costa, Rui

Klotho proteins, αKlotho, βKlotho, and γKlotho, exert tumor-suppressive activities via the fibroblast growth factor receptors and multiple cell-signaling pathways. There is a growing interest in Klotho proteins as potential diagnostic and prognostic biomarkers for multiple diseases. However, recent advances regarding their roles and potential applications in cancer remain disperse and require an integrated anal...


Malignancy associated with Low-Risk HPV6 and HPV11: a systematic review and imp...

Faustino-Rocha, AI; Lima da Silva, L; Teles, AM; Santos, JMO; Souza de Andrade, M; Medeiros, R; Oliveira, PA; Azevedo dos Santos, AP; Lopes, FF; Braz, G

Vaccination against human papillomavirus (HPV) helps prevent cancer caused by this virus. Determining which viral genotypes should be included is key for developing successful vaccination strategies. Low-risk genotypes, especially HPV6 and HPV11, are associated with benign warts. However, some studies also report their presence in cancers. We reviewed the scientific literature to estimate the proportion of canc...


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