2 documents found, page 1 of 1
A SOX2 reporter system identifies gastric cancer stem-like cells sensitive to m...
Pádua, D; Barros, R; Amaral, AL; Mesquita, P; Freire, AF; Sousa, M; Maia, AF; Caiado, I; Fernandes, H; Pombinho, AR; Pereira, CF; Almeida, RGastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to isolate stem-like cells in human gastric cancer cell lines using a traceable reporter system based on SOX2/OCT4 acti...
Expression and clinical relevance of SOX9 in gastric cancer
Mesquita, P; Freire, AF; Lopes, N; Gomes, R; Azevedo, D; Barros, R; Pereira, B; Cavadas, B; Pópulo, H; Boaventura, P; David, L; Pereira, L; Almeida, RGastric cancer is one of the most frequent tumours and the third leading cause of cancer-related death worldwide. The investigation of new biomarkers that can predict patient outcome more accurately and allow better treatment and follow-up decisions is of crucial importance. SOX9 (sex-determining region Y (SRY)-box 9) is a regulator of cell fate decisions in embryogenesis and adulthood. Here, we sought to ascer...