35 documents found, page 1 of 4
Expert consensus and current landscape of NUT carcinoma: A comprehensive strate...
Lopes, JM<jats:p>Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUT midline carcinoma family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis and treatment remain unavailable, underscoring the need for expert consensus. To address this gap, we conducted a systematic review to gather comprehensive information...
INR vs Doseamento de Fator X Cromogénico e Fator II: C em Doentes com Síndrome ...
Campos, MM; Lopes, JM; Marques, MJ; Rincón, F; Fernandes, AI; Ribeiro, ME; Silva, ACOs fatores dependentes da vitamina K podem estar diminuídos de modo variável, sendo o Fator (F) II e o FX os principais determinantes relativamente ao efeito antitrombótico. A ligação dos anticorpos antifosfolipídicos aos fosfolípidos pode causar um falso prolongamento do tempo de protrombina (TP) em doentes com anticoagulante lúpico. Correlacionámos os resultados da razão normalizada internacional (INR) – usan...
The role of c-Met and VEGFR2 in glioblastoma resistance to bevacizumab
Carvalho, B; Lopes, JM; Silva, R; Peixoto, J; Leitão, D; Soares, P; Fernandes, AC; Linhares, P; Vaz, R; Lima, JDismal prognosis of glioblastoma (GBM) prompts for the identification of response predictors and therapeutic resistance mechanisms of current therapies. The authors investigated the impact of c-Met, HGF, VEGFR2 expression and microvessel density (MVD) in GBM patients submitted to second-line chemotherapy with bevacizumab. Immunohistochemical expression of c-Met, HGF, VEGFR2, and MVD was assessed in tumor specim...
TERTp mutations and p53 expression in head and neck cutaneous basal cell carcin...
Castanheira, A; Vieira, MJ; Pinto, M; Dias, C; Prada, L; Macedo, S; Fernandes, MS; Vieira, F; Soares, P; Mota, AV; Lopes, JM; Boaventura, PCutaneous basal cell carcinoma (cBCC) is an economic burden to health services, due to its great morbidity and increasing incidence in old people. Infiltrative cBCCs and cBCCs with micronodular pattern are considered as more aggressive. The role of p53 expression and TERTp mutation on cBCC behavior remains to be clarified. We aimed to assess TERTp mutations and p53 expression in relation to the cBCC histologica...
Combinatorial therapies to overcome braf/mek inhibitors resistance in melanoma ...
Pópulo, H; Domingues, B; Sampaio, C; Lopes, JM; Soares, PBackground: Melanoma accounts for only 1% of all skin malignant tumors; however, it is the deadliest form of skin cancer. Since 2011, FDA (Food and Drug Administration) approved several novel therapeutic strategies, such as MAPK pathway targeted therapies, to treat cutaneous melanoma patients. However, their improvements in overall survival were limited, due to the development of resistance. Methods: In this wo...
Regulation of invasion and peritoneal dissemination of ovarian cancer by mesoth...
Coelho, R; Ricardo, S; Amaral, AL; Huang, YL; Nunes, M; Neves, JP; Mendes, N; López, MN; Bartosch, C; Ferreira, V; Portugal, R; Lopes, JM; Almeida, RPeritoneal dissemination is a particular form of metastasis typically observed in ovarian cancer and the major cause for poor patient’s outcome. Identification of the molecular players involved in ovarian cancer dissemination can offer an approach to develop treatment strategies to improve clinical prognosis. Here, we identified mesothelin (MSLN) as a crucial protein in the multistep process of peritoneal disse...
Prognostic significance of RAS mutations and P53 expression in cutaneous squamo...
Campos, MA; Macedo, S; Fernandes, MS; Pestana, A; Pardal, J; Batista, R; Vinagre, J; Sanches, A; Baptista, A; Lopes, JM; Soares, PTP53 is considered the most commonly-altered gene in cutaneous squamous cell carcinoma (cSCC). Conversely, RAS mutations have been reported in a low percentage of cSCC. The objective of our study was to evaluate the frequency of p53 expression and RAS mutations in cSCC and correlate them with clinicopathological features and patient outcome. We performed immunohistochemistry for p53 and genetic profiling for RA...
Erratum to “Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in...
Santos, AP; Vinagre, J; Soares, P; Claro, I; Sanches, AC; Gomes, L; Fernandes, I; Catarino, AL; Preto, J; Pereira, BD; Marques, AP; Rodrigues, FIn the article titled "Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism"[1], the affiliation for I. Claro was labeled incorrectly. The correct affiliation of the author I. Claro is Instituto Portugûes de Oncologia de Lisboa, Francisco Gentil (IPOLFG), 1099-023 Lisboa, Portugal.
Results of Total Cervical Disc Replacement with a Minimum Follow-up of 10 Years
Lobo, JPFM; Linhares, DVBR; Lopes, JM; Rodrigues, PC; Pinto, RP; Neves, NObjective In the present study, we present the results with at least 10 years of follow-up of the cervical disc prosthesis implanted in a single level. Methods Retrospective study of patients undergoing single-level total cervical disc replacement (TCDR). Clinical results included the neck disability index (NDI) and the visual analogue scale (VAS) in the preoperative period, one year postoperatively, and a mini...
Head and neck cutaneous basal cell carcinoma: What should the otorhinolaryngolo...
Castanheira, A; Boaventura, P; Clemente, MP; Soares, P; Mota, AV; Lopes, JMCutaneous basal cell carcinoma (cBCC) is the most common malignancy diagnosed in the human population. cBCC presents an increasing incidence which, in the near future, will be higher than all other cancers combined. The majority of cBCC are located in the head and the neck. A diversity of management modalities is currently available; nonetheless, surgical excision remains the main modality of treatment. cBCC ra...