12 documents found, page 1 of 2
Interação Tangível: Avaliação da usabilidade de uma Ferramenta Educacional Tang...
Jurgina, Laura Quevedo; Medeiros, Eduarda P.; Mackedanz, Tiago D.; Lopes, João Pedro; Aquini, Lui Gill; Moreira, Fernando; Rosa Júnior, Leomar Soares daEste trabalho explora a usabilidade do Alfaba, uma ferramenta educacional tangível e multissensorial destinada a apoiar a alfabetização, analisada sob a perspectiva de crianças e jovens com síndrome de Down. [...]
MBA para Gestores e Engenheiros -Cap 3 - A Marca Própria
Silvério, Marta; Lopes, João PedroNos dias de hoje a marca possui uma elevada importância estratégia para todas as organizações, no sentido em que uma marca passou a ter um ou vários produtos. Como forma de resposta às mudanças do mercado, nas últimas décadas verificou-se um crescimento exponencial das marcas próprias, o que provocou alterações ao nível das estratégias dos retalhistas e da apetência dos consumidores por estas marcas. A estratég...
Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic In...
Lopes, Cátia R.; Gonçalves, Francisco Q.; Olaio, Simão; Tomé, Ângelo R.; Cunha, Rodrigo A.; Lopes, João PedroAdenosine operates a modulation system fine-tuning the efficiency of synaptic transmission and plasticity through A1 and A2A receptors (A1R, A2AR), respectively. Supramaximal activation of A1R can block hippocampal synaptic transmission, and the tonic engagement of A1R-mediated inhibition is increased with increased frequency of nerve stimulation. This is compatible with an activity-dependent increase in extrac...
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potenti...
Lopes, Cátia R.; Silva, Joana S; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; Lourenço, Vanessa S.Alzheimer's disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of early AD. These animals showed learning and memory deficits in the Morris water maze, increased thigmotaxis and anxiet...
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Ad...
Lopes, Cátia R.; Oliveira, Andreia; Gaspar, Ingride L.; Rodrigues, Matilde S.; Santos, Joana; Szabó, Eszter; Silva, Henrique B.; Tomé, Ângelo R.Adenosine receptors mainly control synaptic function, and excessive activation of adenosine receptors may worsen the onset of many neurological disorders. Accordingly, the regular intake of moderate doses of caffeine antagonizes adenosine receptors and affords robust neuroprotection. Although caffeine intake alters brain functional connectivity and multi-omics analyses indicate that caffeine intake modifies syn...
Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity ...
Lopes, Cátia R.; Silva, Antonio C.; Silva, Henrique B.; Canas, Paula M.; Agostinho, Paula M.; Cunha, Rodrigo A.; Lopes, João PedroThe intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer's disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the blockade of adenosine A2A receptors (A2AR). Since A2AR overfunction is sufficient to trigger memory deficits, we tested if A2AR were upregulated in hippocampal synapses...
Influência de nanotubos de carbono sobre o desempenho de concreto e de concreto...
Lopes, João Pedro; Ferrari, Vladimir José; Camões, Aires; Souza, Aloysio; Fangueiro, RaúlO concreto é um material com elevada frequência de utilização em construções brasileiras e em edificações de países ao redor do mundo. Fatores como os custos reduzidos dos materiais, elevado volume de pesquisa e resistência elevada, colaboram para a grande utilização do concreto como material de construção. Entretanto, o concreto tem baixa resistência à tração, fissura facilmente e apresenta pequena capacidade ...
Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory ...
Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A AThe increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unk...
Characterization of reinforced concrete with steel fibers and carbon nanotubes ...
Lopes, João Pedro; Ferrari, Vladimir; Souza Filho, Aloysio Gomes de; Camões, Aires; Fangueiro, RaúlThis work has as main objective the evaluation of the effect of the content of hybrid fibers on the flexural strength, toughness and residual resistances of reinforced concrete with hybrid fibers (RFC) of steel and carbon nanotubes (CNT). Three different quantity of CNT were previously dispersed by ultrasonication using a Pluronic F-127 surfactant concentration. A fixed quantity of steel fibers was used in conc...
Effects of nanoparticles on the mechanical behaviour of fibre-reinforced concrete
Lopes, João Pedro; Ferrari, Vladimir José; Camões, Aires; Souza, Aloysio; Fangueiro, RaúlThe tensile behaviour of concrete corresponds to approximately 10% of its compressive strength. This limitation can be overcome with the incorporation of short fibres in concrete. Adding fibres to concrete increases its direct tensile strength, flexural tensile strength, toughness and ductility, and improves its crack resistance and ability to absorb energy after cracking. This paper focuses on the effect of th...