11 documents found, page 1 of 2
Neoplasias cefalopancreáticas – Nova abordagem em Anatomia Patológica
Silva , Susana; Simplício , Mariana; Campos, Elisabete; Lopes, Joanne; Almeida , Marinho de; Cristino, Humberto; Graça, Luís; Carneiro, FátimaEnquadramento: A duodenopancreatectomia cefálica (DPC) é uma cirurgia complexa, realizada principalmente para o tratamento de neoplasias malignas ou pré-malignas da cabeça do pâncreas, região periampular e ducto biliar distal. O correto manuseamento macroscópico das amostras de DPC é fundamental para uma avaliação histopatológica precisa, incluindo a origem do tumor, o envolvimento das margens/superfícies cirúr...
Comparing the continuous geboes score with the Robarts Histopathology Index: de...
Magro, Fernando; Lopes, Joanne; Borralho, Paula; Lopes, Susana; Coelho, Rosa; Cotter, Jose; de Castro, Francisca Dias; Sousa, Helena TavaresBackground and Aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and...
Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic act...
Magro, Fernando; Lopes, Susana; Silva, Marco; Coelho, Rosa; Portela, Francisco; Branquinho, Diogo; Correia, Luís; Fernandes, Samuel; Cravo, MaríliaSuppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in the mucosa and serum of ulcerative colitis (UC) patients. We evaluated soluble ST2 (sST2) as a surrogate biomarker of disease outcome and therapeutic response, in moderate-to-severe UC patients treated with golimumab.
Comparison of different histological indexes in the assessment of UC activity a...
Magro, Fernando; Lopes, Joanne; Borralho, Paula; Lopes, Susana; Coelho, Rosa; Cotter, Jose; de Castro, Francisca Dias; Sousa, Helena TavaresObjective Histological remission is being increasingly acknowledged as a therapeutic endpoint in patients with UC. The work hereafter described aimed to evaluate the concordance between three histological classification systems-Geboes Score (GS), Nancy Index (NI) and RobartsHistopathologyIndex (RHI), as well as to evaluate their association with the endoscopic outcomes and the faecal calprotectin (FC) levels. D...
Molecular Staging of Patients with Colon Cancer. The C-Closer-II Study: A Multi...
Brito, María José; Honavar, Mrinalini; Cipriano, Maria Augusta; Lopes, Joanne; Coelho, Helder; Silva, António Rodrigues da; Silva, MárioIntroduction: Approximately 20% - 30% of histological lymph node-negative patients with colorectal cancer relapse at five years after surgical treatment. This recurrence is likely due to occult nodal disease undetected by standard histopathological practice which has implications in terms of the clinical management of patients.Material and Methods: Lymph nodes were collected from colectomy specimens. A central ...
Neoplasia Gástrica: Peculiaridades do Adenocarcinoma Mucinoso
Oliveira, Ana Pinho; Mota, Alexandre; Figueiredo, Ângela; Lopes, Joanne; Martins, Cláudia; Santos, Carla FerreiraGastric mucinous adenocarcinoma, a rare histological subtype of gastric cancer, is characterized by the presence of calcifications which, together with other peculiarities, allows its suspicion by currently available imaging techniques. The authors describe the case of a patient with this subtype of gastric neoplasia and revise its imaging and pathophysiological characteristics.
Accuracy of faecal calprotectin and neutrophil Gelatinase B-associated Lipocali...
Magro, Fernando; Lopes, Susana; Coelho, Rosa; Cotter, Jose; Castro, Francisca Dias de; Sousa, Helena Tavares; Salgado, Marta; Andrade, PatríciaBackground and Aims: Mucosal healing and histological remission are different targets for patients with ulcerative colitis, but both rely on an invasive endoscopic procedure. This study aimed to assess faecal calprotectin and neutrophil gelatinase B-associated lipocalin as biomarkers for disease activity in asymptomatic ulcerative colitis patients. Methods: This was a multicentric cross-sectional study includin...
Clinical performance of an infliximab rapid quantification assay
Magro, Fernando; Afonso, Joana; Lopes, Susana; Coelho, Rosa; Gonçalves, Raquel; Caldeira, Paulo; Lago, Paula; Sousa, Helena Tavares; Ramos, JaimeBackground: Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients. This study aimed to explore a rapid IFX-quantification test from a clinical perspective. Methods: This manuscript describes a prospective cohort study involving 110 ulcerative colitis (UC) patients on the maintenance phase of IFX. IFX trough levels were q...
Calprotectin and the Magnitude of Antibodies to Infliximab in Clinically-stable...
Magro, Fernando; Afonso, Joana; Lopes, Susana; Coelho, Rosa; Gonçalves, Raquel; Caldeira, Paulo; Lago, Paula; Sousa, Helena Tavares; Ramos, JaimeAlthough infliximab (IFX) is an efficient therapy for ulcerative colitis (UC) patients, a considerably high rate of therapeutic failures still occurs. This study aimed at a better understanding of IFX pharmacokinetics and pharmacodynamics among clinically-asymptomatic UC patients. This was a multicentric and prospective study involving 65 UC patients in the maintenance phase of IFX therapy. There were no signif...
Severe acute hepatitis C with spontaneous cure.
Marques, Margarida; Cardoso, Hélder; Vale, Ana Maria Horta; Lopes, Joanne; Macedo, GuilhermeHepatitis C virus (HCV) is responsible for 20% of all cases of acute hepatitis. However, acute C infection isn't usually recognized in clinical practice, once most of the patients are asymptomatic and, in rare cases, the acute infection can progress to a fulminant form. In 40% of HCV infections, the mode of transmission persist unknown. Nosocomial transmission is, nowadays, recognized as a way of infection. Her...