7 documents found, page 1 of 1
Influence of COVID-19 on patients with esophageal varices under prophylactic en...
Craciun, Ana; Botto, Inês; Lopes, Joao; Moura, Miguel; Carvalhana, Sofia; Cortez-Pinto, Helena; Marinho, RuiBackground and objectives: Endoscopic band ligation (EBL) plays a critical role in patients with clinically significant portal hypertension, as variceal eradication (VE) is essential to prevent further variceal upper gastrointestinal bleeding (GI). The emergence of COVID-19 has led to a dramatic reduction in endoscopic activity. Our study aimed to evaluate the effect of COVID-19 on VE, GI, and 6-month mortality...
Intranasal drug delivery for treatment of Alzheimer's disease
Fonseca, Leonor Cancela; Lopes, Joao; Vieira, Joao; Viegas, Claudia; Oliveira, Claudia S.; Hartmann, Rafael P.; Fonte, PedroThe Alzheimer's disease is a neurodegenerative condition with severe consequences interfering with patient quality of life. It is characterized as a progressive and irreversible brain disorder hampering memory and thinking, affecting the capacity to perform daily tasks leading to physical and cognitive incapacitation. The conventional treatment occurs by the oral route, but it presents relevant drawbacks such a...
Assist-as-needed impedance control strategy for a wearable ankle robotic orthosis
Lopes, Joao; Pinheiro, Cristiana; Figueiredo, Joana; Reis, L. P.; Santos, CristinaThe use of robots in rehabilitation attempts an effective, compliant, and time-efficient gait recovery while adapting the assistance to the user's needs. Assist-as-needed strategies (AAN), such as adaptive impedance control, have been reported as prominent strategies to enable this recovery effects. This study proposes an interaction-based assist-as-needed impedance control strategy for an ankle robotic orthosi...
Late hospital arrival for thrombolysis after stroke in Southern Portugal: Who i...
Sobral, Sofia; Taveira, Isabel; Seixas, Rui; Vicente, Ana Claudia; Duarte, Josiana; Goes, Ana Teresa; Duran, David; Lopes, Joao; Rita, HenriqueBackground: Delayed hospital arrival remains the main reason for the low rates of thrombolysis in eligible acute ischemic stroke (AIS) patients. The role of socioeconomic and clinical factors for the prehospital delay of AIS remains poor and has never been studied in Portugal. Objectives: Describe the socioeconomic and clinical factors leading to delayed hospital admission of AIS patients eligible to thrombolys...
Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic...
Santos, João; Mendes-Silva, Leonardo; Afonso,Vanessa; Martins, Gil; Machado, Rui; Lopes, Joao; Cancela, M. Leonor; Futschik, MatthiasMutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs cardiac differentiation. We have now determined that Cited2 depletion in ESC affects the expression of transcription factors and cardiopoietic genes involved i...
Interpreting measures of tuberculosis transmission: a case study on the Portugu...
Lopes, Joao; Rodrigues, Paula; Pinho, Suani TR; Andrade, Roberto FS; Duarte, Raquel; Gomes, M Gabriela MTuberculosis remains a high burden for Human society despite considerable investments in its control. Unique features in the history of infection and transmission dynamics of tuberculosis pose serious limitations on the direct interpretation of surveillance data and call for models that incorporate latent processes and simulate specific interventions.
Insights into the demographic history of african pygmies from complete mitochon...
Batini, Chiara; Lopes, Joao; Behar, Doron M.; Calafell, Francesc; Jorde, Lynn B.; van der Veen, Lolke; Quintana-Murci, Lluis; Spedini, GabriellaPygmy populations are among the few hunter-gatherers currently living in sub-Saharan Africa and are mainly represented by two groups, Eastern and Western, according to their current geographical distribution. They are scattered across the Central African belt and surrounded by Bantu-speaking farmers, with whom they have complex social and economic interactions. To investigate the demographic history of Pygmy gr...