15 documents found, page 1 of 2
Seroprevalence of Protective Antibodies Against Influenza and the Reduction of ...
Guiomar, R; Pereira da Silva, S; Costa, I; Conde, P; Cristóvão, P; Rodrigues, AP; Fernandes, A; Dias, AP; Couto, AR; Ramos, A; Moita, C; Rodrigues, CBackground: Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate. Methods: We conducted an annual repeated cross-sectional seroepidemiologica...
HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed ...
Pingarilho, M; Pimentel, V; Miranda, M; Silva, AR; Diniz, A; Ascenção, B; Piñeiro, C; Koch, C; Rodrigues, C; Caldas, C; Morais, C; Faria, DObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...
Chlamydia Trachomatis: When the Virulence-Associated Genome Backbone Imports a ...
Borges, V; Cordeiro, D; Salas, AI; Lodhia, Z; Correia, C; Isidro, J; Fernandes, C; Rodrigues, AM; Azevedo, J; Alves, J; Roxo, J; Rocha, M; Côrte-Real, RChlamydia trachomatis is the most prevalent sexually transmitted bacterium worldwide and the causative agent of trachoma. Its strains are classified according to their ompA genotypes, which are strongly linked to differential tissue tropism and disease outcomes [ocular disease, urogenital disease and lymphogranuloma venereum (LGV)]. While the genome-based species phylogenetic tree presents four main clades corr...
Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Prote...
Guiomar, R; Pereira da Silva, S; Conde, P; Cristóvão, P; Maia, AC; Pechirra, P; Rodrigues, AP; Nunes, B; Milho, L; Coelho, AP; Fernandes, A; Caseiro, PINTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portugu...
Infecção pelo Vírus da Hepatite B em Doentes Sujeitos a Terapêutica Imunossupre...
Redondo, I; Sousa, MI; Ramos, G; Fernandes, AT; Côrte-Real, R; Botelho, A; Neves, MMA reactivação do vírus da hepatite B em doentes com neoplasias hematológicas é uma complicação frequente da quimioterapia ou da terapêutica imunomoduladora. Os autores descrevem o caso dum doente com linfoma não-Hodgkin e história de infecção passada pelo VHB que desenvolveu hepatite fulminante após quimioterapia. Os mecanismos de reactivação do VHB são discutidos e as recomendações sobre profilaxia são apresen...
Long-Term and Concentration-Dependent Beneficial Effect of Efavirenz on HDL-Cho...
Pereira, SA; Branco, T; Côrte-Real, R; Germano, I; Lampreia, F; Caixas, U; Monteiro, EAIMS: To investigate the long-term effects of efavirenz on cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C) and triglycerides (TG). METHODS: Thirty-four HIV-infected patients who commenced efavirenz therapy were monitored for 36 months. RESULTS: In patients with baseline HDL-C<40 mg.dL-1 an increase in HDL-C from 31+/-1 mg.dL-1 to 44+/-2 mg.dL-1 (95% confidence int...
Immunologic and epidemiologic characterization of non-responders/low-responders...
Ramos, I; Oliveira, J; Alves, V; Côrte-Real, R; Santos-Rosa, M; Silvestre, A MAn important reduction in morbidity and mortality due to hepatitis B was achieved with the discovery of an effective vaccine. However, 2 to 10% of healthy adults do not respond to vaccination with the production of protective levels of antibody anti-HBs (assumed as protective, concentrations of ab. anti-HBs > 10 UI/L). Therefore, the aim of the present work was to study epidemiological (sex, age, obesity, alcoh...
The determination of susceptibility to measles, rubella, mumps and chickenpox i...
Oliveira, J; Dias, N; Ferreira, T M; da Cunha, S; Costa, D; Côrte-Real, R; Meliço-Silvestre, AWe present an epidemiological and serological study in 286 health care students. We found susceptibility for measles in 11.7% individuals (95% confidence interval (95% CI): 8.0-15%), for rubella: 6.7% (95% CI: 3.8-9.6%) for mumps: 12.7% (95% CI: 8.0-16.6%) and for varicella 8.5% (95% CI: 5.3-11.7%). Compared to a similar study, performed in 1992 in a population of health care workers, we found an increasing sus...
Rickettsia infections in Portugal.
Oliveira, J; Côrte-Real, RAfter a brief introduction about rickettsioses, we analyse Mediterranean Spotted Fever (MSF) in Portugal, and review Portuguese medical literature. We focussed on the seasonal summer pattern of the disease. MSF is very frequent in Portugal, nearly 1,000 cases are reported every year and young age groups are the most afflicted. Although usually regarded as a benign condition, MSF has emerged as a potentially let...
The prevalence of measles, rubella, mumps and chickenpox antibodies in a popula...
Oliveira, J; da Cunha, S; Côrte-Real, R; Sampaio, L; Dais, N; Meliço-Silvestre, AWe present an epidemiological and serological study in 409 health care workers randomly selected from the 4,103 workers of the University Hospital of Coimbra. A low level of susceptibility for measles (1.2%; 95% confidence interval (95% CI): 0.15-2.23%), rubella (2.4%; 95% CI: 0.9-3.9) and varicella (3.2%; 95% CI: 1.5-4.7%) and a very high one for mumps (17.3%; 95% CI: 13.7-21.1%), were found. Ineffectiveness o...