2 documents found, page 1 of 1
Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits a...
Batalha, V. L.; Pêgo, José M.; Fontinha, B. M.; Costenla, A. R.; Valadas, J. S.; Baqi, Y.; Radjainia, H.; Müller, C. E.; Sebastião, A. M.; Lopes, L. V.Maternal separation (MS) is an early life stress model that induces permanent changes in the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial working memory. There are compelling evidences for a role of hippocampal adenosine A(2A) receptors in stress-induced modifications related to cognition, thus opening a potential window for therapeutic intervention. Here, we submitted ...
Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dep...
Lopes, L. V.; Cunha, R. A.; Kull, B.; Fredholm, B. B.; Ribeiro, J. A.Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A2A receptor activation or from indirect control of inhibitory GABAergic transmission. The A2A receptor agonist, CGS 21680 (10 nM), facilitated synaptic transmission in the CA1 area of rat hippocampal slices (b...