10 documents found, page 1 of 1
Dual and sequential drug delivery systems with antimicrobial and bone regenerat...
Rodrigues, Miguel A.; Ferreira, Carla; Borges, João P.; Bernardes, Beatriz G.; Oliveira, Ana L.; Santos, José D.; Lopes, Maria A.Bone defect healing is often compromised by infections acquired during surgery, hindering regeneration. An effective solution should first prevent infection and then promote bone repair. Localised drug-delivery systems capable of dual and sequential release of antimicrobial and bone-regenerative agents represent a promising solution; however, precisely controlling this sequential release remains an unmet challe...
Amination of polymeric braid structures to improve tendon healing: An experimen...
Peixoto, Tânia; Silva, Daniel; Rodrigues, Miguel; Neto, Miguel; Silva, Rui; Paiva, Maria C.; Grenho, Liliana; Fernandes, Maria Helena; Lopes, Maria A.Several polymers are researched for tendon repair as polyethylene terephthalate (PET) and polylactic acid (PLA). These are biocompatible and useful in scaffolding repair though with minimal success due to long-term failure. There is a need to improve such scaffolds’ design and physical–chemical nature. This work concerns surface functionalization of polymeric braids (PET and PLA) that fulfill the high mechanica...
Hybrid structures for Achilles' tendon repair
Peixoto, Tânia; Carneiro, Sofia; Pereira, Fábio; Santos, Cristóvão; Fangueiro, Raúl; Duarte, Isabel; Paiva, Maria C.; Lopes, Maria A.; Guedes, Rui M.The management of extensive tendon injuries poses a considerable challenge. These cases typically require a partial replacement of the tissue, and conventional treatment options, either grafts or synthetic constructs, present disadvantages. Synthetic constructs may be produced with either non-biodegradable or biodegradable polymers. However, while the former lacks biointegration, the latter requires a compromis...
Poly(lactic acid) composites with few layer graphene produced by noncovalent ch...
Peixoto, Tânia; Nunes, Joana; Lopes, Maria A.; Marinho, Elina Margarida Ribeiro; Proença, M. Fernanda R. P.; Lopes, Paulo Estevão CaldeiraIn recent years, significant attention has been given to “green” product innovation and related manufacturing processes. This work reports the preparation of few-layer graphene (FLG) and respective PLA-based composites by an ecofriendly, efficient, and cost-effective approach. FLG was produced in a scaledup process, based on the noncovalent functionalization of a micronized graphite with a pyrene derivate (PY),...
Engineering hybrid textile braids for tendon and ligament repair application
Peixoto, Tânia; Carneiro, Sofia; Fangueiro, Raúl; Guedes, Rui M.; Paiva, Maria C.; Lopes, Maria A.Challenges involving tendon and ligament repair have motivated the investigation of new strategies to improve clinical outcomes. These have been mainly based on polymer constructs, which may be non-biodegradable or biodegradable. The former typically fails due to lack of device integration and the latter demands a complex balance between biodegradability and tissue ingrowth, often failing due to insufficient me...
Hybrid structures for Achilles' tendon repair
Peixoto, Tânia; Carneiro, Sofia; Pereira, Fábio; Santos, Cristóvão; Fangueiro, Raúl; Duarte, Isabel; Paiva, Maria C.; Lopes, Maria A.; Guedes, Rui M.The management of extensive tendon injuries poses a considerable challenge. These cases typically require a partial replacement of the tissue, and conventional treatment options, either grafts or synthetic constructs, present disadvantages. Synthetic constructs may be produced with either non-biodegradable or biodegradable polymers. However, while the former lacks biointegration, the latter requires a compromis...
Amination of polymeric braid structures to improve tendon healing: an experimen...
Peixoto, Tânia; Silva, Daniel; Rodrigues, Miguel; Neto, Miguel; Silva, Rui Ramos; Paiva, Maria C.; Grenho, Liliana; Fernandes, Maria HelenaSeveral polymers are researched for tendon repair as polyethylene terephthalate (PET) and polylactic acid (PLA). These are biocompatible and useful in scaffolding repair though with minimal success due to long-term failure. There is a need to improve such scaffolds' design and physical–chemical nature. This work concerns surface functionalization of polymeric braids (PET and PLA) that fulfill the high mechanica...
Potential of Graphene–Polymer composites for ligament and tendon repair: a review
Peixoto, Tânia; Paiva, M. C.; Marques, António T.; Lopes, Maria A.Tendon/ligament injuries are debilitating conditions that affect the life quality of a great percentage of the adult population. Several challenges still have to be addressed regarding the repair of these tissues, as current treatments show limited success. The use of biocompatible and biodegradable polymeric scaffolds potentially helps accomplish a complete and long-term functional repair but, unfortunately, t...
Development and characterization of ZnO piezoelectric thin films on polymeric s...
Ferreira, Armando José Barros; Vaz, F.; Costa, José; Peixoto, Tânia; Lopes, Maria A.Currently available scaffolds for tissue repair have shown very limited success, so many efforts have being put in the development of novel functional materials capable of regulating cell behavior and enhance the tissue healing rate. Piezoelectric materials, as zinc oxide (ZnO), can be a very interesting solution for scaffold development, as they can deliver electrical signals to cells upon mechanical solicitat...
Smart electroconductive bioactive ceramics to promote in situ electrostimulatio...
Mata, Diogo; Oliveira, Filipe J.; Neto, Miguel A.; Belmonte, Manuel; Bastos, Alexandre C.; Lopes, Maria A.; Gomes, Pedro S.; Fernandes, Maria H.Biomaterials can still be reinvented to become simple and universal bone regeneration solutions. Following this roadmap, conductive CNT-based \"smart\" materials accumulate exciting grafting qualities for tuning the in vitro cellular phenotype. Biphasic electrical stimulation of human osteoblastic cells was performed in vitro on either dielectric bioactive bone grafts or conductive CNT-reinforced composites. Th...