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Noncoplanar beam angle optimization in IMRT treatment planning using pattern se...

Rocha, Humberto; Dias, Joana M.; Ferreira, Brígida C.; Lopes, Maria C.


Beam angle optimization for intensity-modulated radiation therapy using a guide...

Rocha, Humberto; Dias, Joana M.; Ferreira, Brígida C.; Lopes, Maria C.

Generally, the inverse planning of radiation therapy consists mainly of the fluence optimization. The beam angle optimization (BAO) in intensity-modulated radiation therapy (IMRT) consists of selecting appropriate radiation incidence directions and may influence the quality of the IMRT plans, both to enhance better organ sparing and to improve tumor coverage. However, in clinical practice, most of the time, bea...


Differential postreceptor signaling events triggered by excitotoxic stimulation...

Santos, Armanda E.; Carvalho, Ana L.; Lopes, Maria C.; Carvalho, Arsélio P.

The aim of this work was to investigate whether excitotoxicity induced by overstimulation of different ionotropic glutamate receptors could trigger different intracellular signaling cascades. Cultured chick neuronal retina cells, essentially amacrine-like, were particularly sensitive to the toxicity induced by non-NMDA glutamate receptor agonists. One hour stimulation with 100 muM kainate induced a reduction of...


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