24 documents found, page 1 of 3
Towards the Sustainable Exploitation of Salt-Tolerant Plants: Nutritional Chara...
Lopes, Maria Celeste; Silva, Ana Sanches; Séndon, Raquel; Barbosa-Pereira, Letricia; Cavaleiro, Carlos; Ramos, FernandoIncreasing soil salinisation represents a serious threat to food security, and therefore the exploitation of high-yielding halophytes, such as Salicornia and Sarcocornia, needs to be considered not merely in arid regions but worldwide. In this study, Salicornia ramosissima and Sarcocornia perennis alpini were evaluated for nutrients, bioactive compounds, antioxidant capacity, and contaminants. Both were shown t...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Lopes, Maria CelesteThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
Prognostic stratification of adult primary glioblastoma multiforme patients bas...
González-Tablas, María; Crespo, Inês; Vital, Ana Luísa; Otero, Álvaro; Nieto, Ana Belén; Sousa, Pablo; Patino-Alonso, María CarmenSeveral classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially impro...
Percepções dos professores face à transição para a vida ativa de alunos
Lopes, Maria Celeste; Silva, Alfredo; Alves, João; Paço, ElsaAtualmente, o processo de transição para a vida ativa dos alunos com NEE deve ser entendido como um processo que se constrói ao longo do tempo, onde se destaca a relevância do investimento feito por cada um dos agentes sociais (escola, família, sociedade/comunidade) Neste sentido a presente comunicação resulta de um estudo que teve por objetivo a análise e reflexão das percepções dos professores sobre o process...
Perceção/atitudes dos pais de alunos com NEE face à inclusão
Lopes, Maria Celeste; Marques, Ana; Marques, Bruno; Salgado, ClaudiaAtualmente verifica-se uma evolução do sistema educativo português, no sentido de tornar as escolas públicas verdadeiras comunidades educativas de inclusão, onde todos os alunos têm iguais oportunidades de aprendizagem. O papel da familia no processo de inclusão dos filhos com necessidades educativas especiais é crucial. É quem melhor conhece a criança, possuindo uma informação valiosa que os professores deverã...
Gliomas and the vascular fragility of the blood brain barrier
Dubois, Luiz Gustavo; Campanati, Loraine; Righy, Cassia; D'Andrea-Meira, Isabella; Spohr, Tania Cristina Leite de Sampaio E; Porto-Carreiro, IsabelAstrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tu...
A atual formação de professores no contexto do paradigma inclusivo: algumas con...
Lopes, Maria CelesteA formação profissional dos professores e a educação inclusiva são temas que se interligam e que devem continuar a merecer a atenção de todos os que se inte- ressam pelos problemas educativos. Este artigo pretende, assim, fazer uma pequena refle- xão sobre os temas em questão e contribuir para uma melhor formação e construção de uma escola inclusi- va. Tenta constatar alguns factos e delinear algumas soluções a...
Association between inflammatory infiltrates and isolated monosomy 22/del(22q) ...
Domingues, Patrícia Henriques; Teodósio, Cristina; Otero, Álvaro; Sousa, Pablo; Ortiz, Javier; Macias, María del Carmen García; Gonçalves, Jesús MaríaMeningiomas contain highly variable levels of infiltrating tissue macrophages (TiMa) and other immune cells. In this study we investigated the potential association between the number and immunophenotype of inflammatory and other immune cells infiltrating the tumor as evaluated by multiparameter flow cytometry, and the clinico-biological, cytogenetic and gene expression profile (GEP) of 75 meningioma patients. ...
Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasom...
Francisco, Vera; Costa, Gustavo; Figueirinha, Artur; Marques, Carla; Pereira, Paulo; Neves, Bruno Miguel; Lopes, Maria Celeste; García-Rodríguez, CarmenEthnopharmacological relevance Cymbopogon citratus (DC.) Stapf leaves infusion is used in traditional medicine for the treatment of inflammatory conditions, however little is known about their bioactive compounds. Aim of the study Investigate the compounds responsible for anti-inflammatory potential of Cymbopogon citratus (Cy) on cytokines production induced by lipopolysaccharide (LPS) in human and mouse macrop...
Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammat...
Búfalo, Michelle Cristiane; Ferreira, Isabel; Costa, Gustavo; Francisco, Vera; Liberal, Joana; Cruz, Maria Teresa; Lopes, Maria CelesteEthnopharmacological relevance Propolis is a bee product with numerous biological and pharmacological properties, such as immunomodulatory and anti-inflammatory activities. It has been used in folk medicine as a healthy drink and in food to improve health and prevent inflammatory diseases. However, little is known about its mechanism of action. Thus, the goal of this study was to verify the antioxidant activity...