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In vitro enantioselective inhibition of the main human CYP450 enzymes involved ...

Habenschus, Maísa Daniela; Carrão, Daniel Blascke; de Albuquerque, Nayara Cristina Perez; Perovani, Icaro Salgado; Moreira da Silva, Rodrigo

Made available in DSpace on 2022-04-28T19:43:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-15; Tebuconazole (TEB) is a chiral triazole fungicide worldwide employed to control plant pathogens and preserve wood. People can be exposed to TEB either through diet and occupational contamination. This work investigates the in vitro inhibitory potential of rac-TEB, S-(+)-TEB, and R-(−)-TEB over the main ...

Date: 2022   |   Origin: Oasisbr

Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes

Moreira Da Silva, Rodrigo; De Gaitani, Cristiane Masetto; Marques, Lucas Maciel Mauriz; Fraige Baraco, Karina; Cavalheiro, Alberto José

Made available in DSpace on 2022-04-29T08:45:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in vivo antitumor action have also been described when CAS X was administered intraperi...

Date: 2022   |   Origin: Oasisbr

Enantioselective inhibition of human CYP2C19 by the chiral pesticide ethofumesa...

Perovani, Icaro Salgado; Mariano Bucci, Jade Lorena; Carrão, Daniel Blascke; Santos Barbetta, Maike Felipe; Moreira da Silva, Rodrigo

Made available in DSpace on 2022-04-29T08:45:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-25; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Ethofumesate is a chiral herbicide that may display enantioselective behavior in humans. For this reas...

Date: 2022   |   Origin: Oasisbr

In vitro-in vivo correlation of the chiral pesticide prothioconazole after inte...

Perovani, Icaro Salgado; Santos Barbetta, Maike Felipe; Moreira da Silva, Rodrigo; Lopes, Norberto Peporine

Made available in DSpace on 2022-04-29T08:46:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-05-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Growing human demand for food has culminated in increased use of pesticides worldwide. Prothioconazole...

Date: 2022   |   Origin: Oasisbr

In vitro metabolism of copalic and kaurenoic acids in rat and human liver micro...

Mauro, Mariana [UNESP]; da Silva, Rodrigo Moreira; de Campos, Michel Leandro; Bauermeister, Anelize; Lopes, Norberto Peporine

Made available in DSpace on 2022-04-29T08:32:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Copalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver microsomes using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The in...

Date: 2022   |   Origin: Oasisbr

Eco-Friendly Pharmaceutical Analysis of Rifaximin in Tablets by HPLC-MS and Mic...

Kogawa, Ana Carolina [UNESP]; Mendonça, Jacqueline Nakau; Lopes, Norberto Peporine; Salgado, Hérida Regina Nunes [UNESP]

Made available in DSpace on 2022-05-01T06:02:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-21; Rifaximin, an antimicrobial used for the treatment of various diseases, lacks analytical methods in official compendia for evaluation of the final product. This paper presents an eco-friendly protocol for rifaximin tablets by high performance liquid chromatography coupled with mass spectrometry (HPLC-MS...

Date: 2022   |   Origin: Oasisbr



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