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Prostate cancer treatment in Portugal: a nationwide analysis

Botelho, F; Lopes, R; Pina, F; Silva, C; Pacheco-Figueiredo, L; Lunet, N

Different treatment options exist for localized prostate cancer. Treatments performed in high-volume hospitals are associated with better results. Our objective was to describe time trends in prostate cancer treatments in Portugal and case volume per hospital. We used the national database of diagnosis-related group of the Portuguese Central Administration of the Health System to describe the number of radical ...


Review of Piezoelectrical Materials Potentially Useful for Peripheral Nerve Repair

Casal, D; Casimiro, MH; Ferreira, L; Leal, JP; Rodrigues, G; Lopes, R; Lino Moura, D; Gonçalves, L; Lago, J; Pais, D; Santos, P

It has increasingly been recognized that electrical currents play a pivotal role in cell migration and tissue repair, in a process named "galvanotaxis". In this review, we summarize the current evidence supporting the potential benefits of electric stimulation (ES) in the physiology of peripheral nerve repair (PNR). Moreover, we discuss the potential of piezoelectric materials in this context. The use of these ...


Gynecological History Up to Diagnosis and Pregnancy Outcomes in Diagnosed Wilso...

Roseira, J; Lopes, R; Silva, MJ; Vieira, AM; Sampaio, M; Calinas, F

Introduction: most studies narrowly focus on pregnancy outcome comparisons between Wilson’s disease (WD) patients on and off treatment. We aimed to identify menses irregularities in untreated WD, and to evaluate pregnancy outcomes in treated WD patients as compared to matched controls (with and without liver disease). Methods: females with WD, hepatitis C (liver disease controls), and other gastrointestinal con...


Animal Models of Acute Gastric Mucosal Injury: Macroscopic and Microscopic Eval...

Simões, S; Lopes, R; Dias Campos, MC; Marruz, MJ; Meirinhos da Cruz, ME; Corvo, L

Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute gastric ulcer, the ethanol-induced ulcer and the indomethacin-induced ulcer. These two models are compared in terms of macroscopic and microscopic features. Experimentally,...


Inovar a praxe: integração numa escola de enfermagem promotora de saúde – Escol...

Pedroso, R; Perdigão, A; Armando, S; Brito, I; Paiva, L; Simões, M; Simões, C; Margalho, M; Neves, M; Cristina, R; Lopes, R; Coutinho, V; Parola, Vítor


Dynamics of Epileptic Activity in a Peculiar Case of Childhood Absence Epilepsy...

Leal, A; Vieira, JP; Lopes, R; Nunes, R; Gonçalves, S; Lopes da Silva, F; Figueiredo, P

Childhood absence epilepsy (CAE) is a syndrome with well-defined electroclinical features but unknown pathological basis. An increased thalamic tonic GABA inhibition has recently been discovered on animal models (Cope et al., 2009), but its relevance for human CAE is unproven. METHODS: We studied an 11-year-old boy, presenting the typical clinical features of CAE, but spike-wave discharges (SWD) restricted to o...


Neuropsychological Abnormalities in Children with the Panayiotopoulos Syndrome ...

Lopes, R; Simões, M; Leal, A

Panayiotopoulos syndrome (PS) is a common epilepsy syndrome associated with rare clinical seizures and unknown localization of the epileptogenic area. Despite findings of normal development in patientswith PS, recent neuropsychological studies point to subtle and diverse cognitive impairments. No well-outlined hypothesis about the localization of the brain dysfunction responsible for these impairments has been ...


Prognostic implications of diuretic dose in chronic heart failure

Martins, J; Lourenço, P; Araújo, JP; Mascarenhas, J; Lopes, R; Azevedo, A; Bettencourt, P

Background: Prognostic implications of diuretics dose are not completely understood. We aim to study the association between diuretic doses and long-term prognosis in patients with chronic stable heart failure (HF). Methods and Results: We conducted a retrospective cohort study of 244 patients followed at an outpatient HF clinic. Admission criteria were clinical stability in the previous 3 months and optimized ...


Cor Triatriatum num Adulto Assintomático. Diagnóstico por AngioTC Cardíaca

Ferreira, F; Ferreira, AM; Lopes, R; Ferreira, J; Correia, MG; Gil, VM


N170 Asymmetry as an Index of Inferior Occipital Dysfunction in Patients With S...

Lopes, R; Cabral, P; Canas, N; Breia, P; Foreid, JP; Calado, E; Silva, R; Leal, A

Objective: Localizing epileptic foci in posterior brain epilepsy remains a difficult exercise in surgery for epilepsy evaluation. Neither clinical manifestations, neurological, EEG nor neuropsychological evaluations provide strong information about the area of onset, and fast spread of paroxysms often produces mixed features of occipital, temporal and parietal symptoms. We investigated the usefulness of the N17...


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