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Saccharomyces cerevisiae cells lacking the zinc vacuolar transporter Zrt3 displ...
Terra-Matos, Joana; Teixeira, Marta Oliveira; Pereira, Cátia Sofia Santos; Noronha, Henrique; Domingues, Lucília; Sieiro, Carmen; Gerós, H.Yeast-based bioethanol production from lignocellulosic hydrolysates (LH) is an attractive and sustainable alternative for biofuel production. However, the presence of acetic acid (AA) in LH is still a major problem. Indeed, above certain concentrations, AA inhibits yeast fermentation and triggers a regulated cell death (RCD) process mediated by the mitochondria and vacuole. Understanding the mechanisms involved...
Resveratrol-loaded lipid nanocarriers are internalized by endocytosis in yeast
Barbosa, Célia; Pereira, Cátia S.; Soares, Inês; Martins, Viviana; Terra-Matos, Joana; Côrte-Real, Manuela; Lúcio, M.; Real Oliveira, M. Elisabete C.D.Different positive pharmacological effects have been attributed to the natural product resveratrol (RSV), including antioxidant, antiaging, and cancer chemopreventive properties. However, its low bioavailability and rapid metabolic degradation has led to the suspicion that many of the biological activities of this compound observed in vitro may not be attainable in humans. To improve its bioavailability and pha...