49 documents found, page 1 of 5
Anti-Zika Virus Effects, Placenta Protection and Chemical Composition of Passif...
Xavier,Jadriane A.; Santos,Jaqueline C.; Nova,Monique A. Vila; Gonçalves,Camilla M.; Borbely,Karen S. C.; Pires,Keyla S. N.; Santos,Flávia A. R. dosVarious beneficial biological activities have been reported for passion fruit (Passiflora edulis), grown in tropical and subtropical regions. However, no study has yet demonstrated its action against the Zika virus (ZIKV) infection. The present study aimed to investigate the anti-ZIKV of the ethanolic passion fruit seed extract (PFSE), from which, liquid chromatography tandem mass spectrometry (LC-MS/MS) analys...
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Paly...
Pinto,Francisco C. L.; Silveira,Edilberto R.; Vasconcelos,Ana Caroline L.; Florêncio,Katharine G. D.; Oliveira,Francisca A. S.; Sahm,Bianca B.A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of an...
Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vit...
Clososki,Giuliano C.; Soldi,Rafael A.; Silva,Rodrigo M. da; Guaratini,Thais; Lopes,José N. C.; Pereira,Pâmela R. R.; Lopes,João L. C.; Santos,Thiago dosThe recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led society to live with a serious public health problem. In this sense, repositioning of antiretrovirals has captured the attention of the scientific community. Tenofovir disoproxil fumarate (TDF) is an antiretroviral compound that is used to treat acquired immune deficiency syndrome (AIDS) and hepatitis B. In this short r...
METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS
Pilon,Alan C.; Selegato,Denise M.; Fernandes,Richard P.; Bueno,Paula C. P.; Pinho,Danielle R.; Carnevale Neto,Fausto; Freire,Rafael T.Metabolomics has played a central role in various areas of plant sciences, offering new perspectives for the advancement of agriculture, drug discovery, chemical ecology and taxonomy. Plant metabolomics (identification and quantification) aims to understand the relationship between biological systems and genetic, pathological and or environmental stimuli in terms of differential expression of the metabolism. Ow...
Pharmacokinetic disposition of erythraline in rats after intravenous administra...
Demarque,Daniel P.; Callejon,Daniel R.; Pinto,Larissa G.; Gouvea,Dayana R.; de Moraes,Natália V.; Lopes,João L.C.; Lopes,José N.C.; Lopes,Norberto P.ABSTRACT Erythraline is the major alkaloid produced by Erythrina verna Vell., Fabaceae, a plant used in folk medicine and phytotherapeutic products to treat anxiety and sleep disorders. This study aimed to investigate the pharmacokinetic parameters of erythraline after intravenous administration in rats. For the analysis of erythraline in rat plasma, a method was developed and validated using UHPLC-MS/MS. Pharm...
The role of tannins as antiulcer agents: a fluorescence-imaging based study
Demarque,Daniel P.; Callejon,Daniel R.; Oliveira,Gibson G. de; Silva,Denise B.; Carollo,Carlos A.; Lopes,Norberto P.Abstract Condensed tannins have been used for many years in folk medicine to treat gastric problems. The mechanism of action that explains why tannins improve gastritis symptoms is based on their ability to chelate metals, antioxidant activity, and their complexation power with other molecules. Even though these uses are well-known, the requirements to become an herbal medicine are much more complex. Herein, we...
Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
Silva,Rodrigo M. da; Guaratini,Thais; Jimenez,Paula C.; Fenical,William; Costa-Lotufo,Letícia V.; Vessecchi,Ricardo; Lopes,Norberto P.Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/M...
Ketalization of Ketones to 1,3-Dioxolanes and Concurring Self-Aldolization Cata...
Barbosa,Sandro L.; Ottone,Myrlene; Almeida,Mainara T. de; Lage,Guilherme L. C.; Almeida,Melina A. R.; Nelson,David Lee; Santos,Wallans T. P. dosThe amorphous, mesoporous SiO2-SO3H catalyst with a surface area of 115 m2 g-1 and 1.32 mmol H+ per g was very efficient for the protonation of ketones on a 10% (m/m) basis, and the catalyst-bound intermediates can be trapped by polyalcohols to produce ketals in high yields or suffer aldol condensations within minutes under low-power microwave irradiation. The same catalyst can easily reverse the ketalization r...
Biological activities and phytochemical profile of Passiflora mucronata from th...
Araujo,Marlon H. de; Silva,Isabel C.V. da; Oliveira,Pollyana F. de; Barreto,Arielly R.R.; Konno,Tatiana U.P.; Esteves,Francisco de A.; Barth,ThiagoABSTRACT In general, Passiflora species have been reported for their folk medicinal use as sedative and anti-inflammatory. However, P. caerulea has already been reported to treat pulmonary diseases. Severe pulmonary tuberculosis, generally caused by Mycobacterium tuberculosis strains resistant to multiple drugs, can lead to deleterious inflammation and high mortality, encouraging new approaches in drug discover...
An UPLC-MS/MS Method for Determination of Vicenin-2 and Lychnopholic Acid in Ra...
Gouvea,Dayana R.; Buqui,Gabriela A.; Lopes,João Luis C.; Diniz,Andrea; Lopes,Norberto P.Vicenin-2 (VIC) and lychnopholic acid (LA) are present in large amounts in hydroalcoholic extract from leaves of Lychnophora salicifolia, commonly known in the Brazilian Cerrado as "arnicão", a plant applied as topic anti-inflammatory and as a flavoring agent for the traditional spirit (cachaça). A new ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validat...