19 documents found, page 1 of 2
In vitro metabolism of copalic and kaurenoic acids in rat and human liver micro...
Mauro,Mariana; Silva,Rodrigo Moreira da; Campos,Michel Leandro de; Bauermeister,Anelize; Lopes,Norberto Peporine; Moraes,Natalia Valadares deCopalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver microsomes using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The in vitro assays showed deviations from the Michaelian kinetics in the metabolism of CA and KA. Putative metaboli...
Insecticidal and inhibitory effects of Meliaceae and Asteraceae extracts to sil...
Baldin,Edson Luiz Lopes; Schlick-Souza,Eunice Cláudia; Soares,Muriel Cicatti Emanoeli; Lopes,Norberto Peporine; Lopes,João Luis CallegariABSTRACT Bemisia tabaci (Hemiptera: Aleyrodidae) is a polyphagous insect that causes direct and indirect damage on tomato. Spraying with synthetic insecticides is one of the main control tools for the whitefly; however, the abusive use of this tool can impact the environment and human beings. In this study we evaluated the bioactivity of extracts from plant species from Asteraceae and Meliaceae families on B. t...
EIXOS MOBILIZADORES EM QUÍMICA: UM BREVE OLHAR QUINZE ANOS DEPOIS
Guarieiro,Lilian Lefol Nani; Pereira,Pedro Afonso de Paula; Vieira,Paulo Cezar; Lopes,Norberto Peporine; Andrade,Jailson B. deIn 2002, the Brazilian Chemical Society have promoted several activities aiming to prepare a document to discuss the education in Chemistry in Brazil, the new model of research funding, the area situation and its perspectives. The document drew up diagnoses and brought up proposals that were organized into six mobilizing axes. Among its conclusions it was expected an alignment of scientific and technological re...
Pyrimidine alkaloids from Eudistoma vannamei
Takeara,Renata; Basso,Thiago Olitta; Jimenez,Paula Christine; Costa-Lotufo,Letícia Veras; Lopes,Norberto Peporine; Lopes,João Luis CallegariAbstract Methanolic extracts of the Brazilian endemic ascidian Eudistoma vannamei have been extensively studied for their cytotoxic activity against several human cancer cell lines. Previous work reported the occurrence of purine derivatives and staurosporine alkaloids as the major nitrogen-containing compounds. In this study, we report the occurrence of three pyrimidine alkaloids in addition to cholesterol, si...
Effect of fertilisation and harvest period on polar metabolites of Calendula of...
Fernandes,Eduardo Felipe Alves; Meloni,Fernando; Borella,Júlio Cézar; Lopes,Norberto PeporineThe present study evaluated the chemical profile of polar extracts of Calendula officinalis L., Asteraceae, that were grown under different cultivation conditions: chemical fertilisation, organic fertilisation and mulching. Furthermore, we investigated metabolite variations during plant development by comparing the metabolites from harvested plants at 60 and 120 days after planting. We used HPLC-DAD-MS/MS to te...
Sensitive method for determination of piplartine, an alkaloid amide from Piper ...
Bezerra,Daniel P.; Pessoa,Cláudia; Moraes,Manoel O.; Costa-Lotufo,Letícia V.; Rubio Gouvea,Dayana; Jabor,Valquíria A. Polisel; Lopes,Norberto PeporinePiplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assesse...
Seasonal variation of the major secondary metabolites present in the extract of...
Gouvea,Dayana Rubio; Gobbo-Neto,Leonardo; Sakamoto,Humberto T.; Lopes,Norberto Peporine; Lopes,João Luís Callegari; Meloni,FernandoThe species Eremanthus mattogrossensis, known as "veludo do cerrado" (cerrado velvet), is native to the Brazilian Cerrado. Because the amount of metabolites present in plants may be influenced by biological and environmental factors, here we conducted an HPLC-DAD-MS/MS investigation of the metabolite concentrations found in the MeOH/H2O extract of the leaves of this species. The main compounds were identified a...
Aplicação de espectrometria de massas com ionização por elétron na análise de a...
Feitosa,Luís Guilherme Pereira; Guaratini,Thais; Lopes,João Luis Callegari; Lopes,Norberto Peporine; Bizaro,Aline Cavalli; Silva,Denise Brentan daErythrina verna is a medicinal plant used to calm agitation popularly known as mulungu. We purchased the barks of E. verna from a commercial producer and analyzed the alkaloid fraction of the bark by CG-MS and HRESI-MS. Five erythrinian alkaloids were identified: erysotrine, erythratidine, erythratidinone, epimer, and 11-hydroxieritratidinone. Here we report the compound 11-hydroxieritratidinone for the first t...
Complete ¹H and 13C NMR structural assignments for a group of four goyazensolid...
Soares,Ana Carolina Ferreira; Silva,Aline Nazaré; Matos,Priscilla Mendonça; Silva,Eder Henrique da; Heleno,Vladimir Constantino GomesFour goyazensolide-type sesquiterpene lactones - lychnofolide, centratherin, goyazensolide and goyazensolide acetate - were thoroughly studied by NMR experimental techniques. ¹H NMR, 13C NMR {¹H}, COSY, HMQC, HMBC, J-res. and NOE experiments were performed to provide the needed structural information. Complete and unequivocal assignment, including the determination of all multiplicities, was obtained for each s...
Nomenclaturas de espectrometria de massas em língua portuguesa
Vessecchi,Ricardo; Lopes,Norberto Peporine; Gozzo,Fábio Cesar; Dörr,Felipe Augusto; Murgu,Michael; Lebre,Daniel Temponi; Abreu,RenatoIn commemoration of the International Year of Chemistry this article presents the normalization and standardization of key terms used in mass spectrometry in Portuguese Language.