3 documents found, page 1 of 1
Design of natterins-based peptides improves antimicrobial and antiviral activities
de Cena, Gabrielle L.; Tada, Dayane B.; Lucchi, Danilo B. M.; Santos, Tiago; Heras, Montserrat; Juliano, Maria; Torres Braconi, CarlaThe biochemical analysis of animal venoms has been intensifying over the years, enabling the prediction of new molecules derived from toxins, harnessing the therapeutic potential of these molecules. From the venom of the fish Thalassophryne nattereri, using in silico methods for predicting antimicrobial and cell-penetrating peptides, two peptides from Natterins with promising characteristics were synthesized an...
Design of bioactive peptides derived from CART sequence isolated from the toadf...
Conceição, Katia; de Cena, Gabrielle L.; da Silva, Verônica A.; de Oliveira Neto, Xisto Antonio; de Andrade, Vitor Martins; Tada, Dayane BatistaThe emergence of bacterial resistance due to the indiscriminate use of antibiotics warrants the need for developing new bioactive agents. In this context, antimicrobial peptides are highly useful for managing resistant microbial strains. In this study, we report the isolation and characterization of peptides obtained from the venom of the toadfish Thalassophryne nattereri. These peptides were active against Gra...
Acute-phase proteins during inflammatory reaction by bacterial infection: Fish-...
Charlie-Silva, Ives [UNESP]; Klein, Andre; Gomes, Juliana M. M.; Prado, Ed J. R. [UNESP]; Moraes, Alessandra C. [UNESP]; Eto, Silas F. [UNESP]Made available in DSpace on 2019-10-06T17:05:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Acute-phase protein (APPs) serum levels have been studied in many human diseases, and their components contribute to host defense during the evolution of infectious diseases by acting as part of the innate immune system. Based on the importa...