We examined commercial growth curves of three sheep genotypes in a Second-Grade cooperative context, with Spanish Merino used as a maternal base, Fleischschaf as a paternal base, and crossbred (Fleischschaf × Merino) lambs as the commercial product. We included weight-age data collected from 2013 to 2016 for 9846 lambs of both sexes belonging to 14 herds across the three genotypes. Five of the most-cited models...
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Tacripyrines (1-14) have been designed by combining an ACNE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. Tacripyrines are selective and potent ACNE inhibitors in the nanomolar range. The mixed type inhibition of hAChE activity of compound 11 (IC50 105 +/- 15 nM) is associated to a 30.7 +/- 8.6% inhibition of the p...