2 documents found, page 1 of 1
Roadmap on nanomedicine for the central nervous system
Ciofani, Gianni; Campisi, Marco; Mattu, Clara; Kamm, Roger D.; Chiono, Valeria; Raynold, Aji Alex Moothedathu; Freitas, João S.; Redolfi Riva, EugenioIn recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the stat...
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor act...
Valente, Andreia; Santos, Ana Margarida; Côrte-Real, Leonor; Robalo, Maria Paula; Moreno, Virtudes; Font-Bardia, Merce; Calvet, Teresa; Lorenzo, JuliaA new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of inter...