Encontrados 38 documentos, a visualizar página 1 de 4
Somatosensory evoked potentials in clinical practice: a review
Fustes,Otto Jesus Hernández; Kay,Cláudia Suemi Kamoi; Lorenzoni,Paulo José; Ducci,Renata Dal-Prá; Werneck,Lineu Cesar; Scola,Rosana HerminiaAbstract The authors present a review of the current use of somatosensory evoked potentials (SSEPs) in neurological practice as a non-invasive neurophysiological technique. For this purpose we have reviewed articles published in English or Portuguese in the PubMed and LILACS databases. In this review, we address the role of SSEPs in neurological diseases that affect the central nervous system and the peripheral...
Myasthenia gravis during pregnancy: what care should be taken?
Ducci,Renata Dal-Prá; Kay,Cláudia Suemi Kamoi; Fustes,Otto Jesus Hernandez; Werneck,Lineu Cesar; Lorenzoni,Paulo José; Scola,Rosana HerminiaAbstract Myasthenia gravis (MG) is an autoimmune disease in which the peak incidence is among women of childbearing age. For this reason, there is an overlap between the occurrence of this disease and pregnancy. It is known that MG symptoms can worsen during pregnancy and postpartum, and that pregnancy has special characteristics in MG patients. Children born to myasthenic mothers are at risk of having transien...
Peripheral polyneuropathy from electrodiagnostic tests: a 10-year etiology and ...
Ducci,Renata Dal-Prá; Tessaro,Camila Lorenzini; Kay,Cláudia Suemi Kamoi; Fustes,Otto Jesus Hernandez; Werneck,Lineu Cesar; Lorenzoni,Paulo JoséABSTRACT Background: Polyneuropathies are characterized by a symmetrical impairment of the peripheral nervous system, resulting in sensory, motor and/or autonomic deficits. Due to the heterogeneity of causes, an etiological diagnosis for polyneuropathy is challenging. Objective: The aim of this study was to determine the main causes of polyneuropathy confirmed by electrodiagnostic (EDX) tests in a tertiary serv...
Seventy years since the invention of the averaging technique in Neurophysiology...
Fustes,Otto Jesus Hernández; Kay,Cláudia Suemi Kamoi; Lorenzoni,Paulo José; Ducci,Renata Dal-Prá; Werneck,Lineu Cesar; Scola,Rosana HerminiaABSTRACT In 1951, the physiologist George Duncan Dawson presented his work with the averaging of the signal in the evoked potentials (EPs), opening a new stage in the development of clinical neurophysiology. The authors present aspects of Professor Dawson’s biography and a review of his work on the EPs and, mainly, the article reveals the new technique in detail that would allow the growth of the clinical appli...
Congenital myasthenic syndrome in a cohort of patients with ‘double’ seronegati...
Lorenzoni,Paulo José; Ducci,Renata Dal-Pra; Arndt,Raquel Cristina; Hrysay,Nyvia Milicio Coblinski; Fustes,Otto Jesus Hernandez; Töpf,AnaABSTRACT Background: Congenital myasthenic syndromes (CMS) have some phenotypic overlap with seronegative myasthenia gravis (SNMG). Objective: The aim of this single center study was to assess the minimum occurrence of CMS misdiagnosed as double SNMG in a Brazilian cohort. Methods: The genetic analysis of the most common mutations in CHRNE, RAPSN, and DOK7 genes was used as the main screening tool. Results: We ...
HLA-alleles class I and II associated with genetic susceptibility to neuromyeli...
Kay,Cláudia Suemi Kamoi; Scola,Rosana Herminia; Arndt,Raquel Cristina; Lorenzoni,Paulo José; Werneck,Lineu CesarABSTRACT Objective: To study the genetic susceptibility to neuromyelitis optica (NMO) as well as the relationship between HLA genotypes and susceptibility to the disease in the southern Brazilian population. Methods: We analyzed patients with NMO, who met criteria for Wingerchuk's diagnosis of NMO, with detected serum anti-AQP4-IgG antibody. The HLA genotyping was performed by high-resolution techniques (Sanger...
Duchenne muscular dystrophy: an historical treatment review
Werneck,Lineu Cesar; Lorenzoni,Paulo José; Ducci,Renata Dal-Prá; Fustes,Otto Hernández; Kay,Cláudia Suemi Kamoi; Scola,Rosana HerminiaABSTRACT In this review, we discuss the therapies used in the treatment of patients with Duchenne muscular dystrophy since the first description of the disease. A short description is given of the various theories based on disease pathogenesis, which give the substrates for the many therapeutic interventions. A brief review of the methods of evaluation used in therapeutic trials is made. Of all the treatments, ...
Lambert-Eaton myasthenic syndrome: the 60th anniversary of Eaton and Lambert's ...
Lorenzoni,Paulo José; Kay,Cláudia Suemi Kamoi; Werneck,Lineu Cesar; Scola,Rosana HerminiaABSTRACT This historical review describes the contribution of Drs. Lee M. Eaton and Edward H. Lambert to the diagnosis of myasthenic syndrome on the 60th anniversary of their pioneering article (JAMA 1957) on the disease. There are important landmarks in their article on a disorder of the neuromuscular junction associated with thoracic neoplasm and the electrophysiological criteria for Lambert-Eaton myasthenic ...
Late-onset Pompe disease: what is the prevalence of limb-girdle muscular weakne...
Lorenzoni,Paulo José; Kay,Cláudia Suemi Kamoi; Higashi,Nádia Sugano; D'Almeida,Vânia; Werneck,Lineu Cesar; Scola,Rosana HerminiaABSTRACT Pompe disease is an inherited disease caused by acid alpha-glucosidase (GAA) deficiency. A single center observational study aimed at assessing the prevalence of late-onset Pompe disease in a high-risk Brazilian population, using the dried blood spot test to detect GAA deficiency as a main screening tool. Dried blood spots were collected for GAA activity assay from 24 patients with “unexplained” limb-g...
Multiple sclerosis: disease modifying therapy and the human leukocyte antigen
Werneck,Lineu Cesar; Lorenzoni,Paulo José; Kay,Cláudia Suemi Kamoi; Scola,Rosana HerminiaABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginning and end of each type of DMT including the disease duration, Expanded Disability Status Scale and Multiple Sc...