5 documents found, page 1 of 1
Cerebrovascular mechanism of bisphenol A exposure in stroke ischemic events
Costa, Henrique; Lorigo, Margarida; Cairrão, ElisaBackground: The endocrine-disrupting compound bisphenol A (BPA) is produced in large quantities all over the world and is found in epoxy resins and polycarbonate plastics, which are used to make baby bottles and food and drink storage containers [1]. Due to its androgenic and estrogenic qualities, BPA has been shown to accumulate in brain tissue and is thus linked to negative neurological and vascular outcomes,...
Vascular mechanisms of testosterone: the non-genomic point of view
Lorigo, Margarida; Mariana, Melissa; Lemos, Manuel C.; Cairrão, ElisaTestosterone (T) is the predominant endogenous androgen in the bloodstream. At the vascular level, T presents genomic and non-genomic effects, and both effects may overlap. The genomic actions assume that androgens can freely cross the plasma membrane of target cells and bind to nuclear androgen receptors, inducing gene transcription and protein synthesis. The non-genomic effects have a more rapid onset and may...
Vascular Pathways of Testosterone: Clinical Implications
Lorigo, Margarida; Mariana, Melissa; Oliveira, Nelson; Lemos, Manuel C.; Cairrão, ElisaCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T ...
UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibi...
Lorigo, Margarida; Antunes, Carla; Lemos, Manuel C.; Oliveira, J. Martinez de; Granadeiro, Luiza Breitenfeld; Cairrão, ElisaUltraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the ...
Antioxidants as stabilizers of UV filters: an example for the UV-B filter octyl...
Lorigo, Margarida; Cairrão, ElisaBackground: Sunlight is one of the main harmful exogenous factors that induce the reactive oxygen species formation. The human skin is the first line of photoprotection against harmful exogenous factors, such as UV radiations. The topical application of sunscreens, containing UV-B filters, is widely used to protect against UV-induced damage. Octylmethoxycinnamate is the world’s most widely used UV-B filter in s...